Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel

Magenkrebs-Risiko

Das Risiko eines Magenkarzinoms kann durch genetische Varianten im IL1RN-Gen, welches ein Interleukin 1 kodiert, vermittelt werden.

Gliederung

Erbliche Tumorerkrankungen
Hereditäre Nierentumoren
Hereditäre maligne Bluterkrankungen
Infantiles kapilläres Hämangiom
Multiple selbsheilende palmoplantare Karzinome
Neigung zu Kaposi-Sarkomen
Neurofibromatose

Referenzen:

1.

None (1988) A human model of gastric carcinogenesis.

[^]
2.

Carneiro F et. al. (1995) New elements for an updated classification of the carcinomas of the stomach.

[^]
3.

Guilford P et. al. (1998) E-cadherin germline mutations in familial gastric cancer.

[^]
4.

Gayther SA et. al. (1998) Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.

[^]
5.

Richards FM et. al. (1999) Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.

[^]
6.

Kakiuchi H et. al. () Familial gastric cancer in the Japanese population is frequently located at the cardiac region.

[^]
7.

Guilford PJ et. al. (1999) E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer.

[^]
8.

Caldas C et. al. (1999) Familial gastric cancer: overview and guidelines for management.

[^]
9.

Grady WM et. al. (2000) Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer.

[^]
10.

Lynch HT et. al. (2000) E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma.

[^]
11.

Huntsman DG et. al. (2001) Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations.

[^]
12.

Chun YS et. al. (2001) Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated?

[^]
13.

Oliveira C et. al. (2002) Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred.

[^]
14.

None (1964) FAMILIAL GASTRIC CANCER.

[^]
15.

None (1965) THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.

[^]
16.

Brooks-Wilson AR et. al. (2004) Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria.

[^]
17.

Frebourg T et. al. (2006) Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer.

[^]
18.

Oliveira C et. al. (2009) Germline CDH1 deletions in hereditary diffuse gastric cancer families.

[^]
19.

Fitzgerald RC et. al. (2010) Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research.

[^]
20.

Benusiglio PR et. al. (2013) CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study.

[^]
21.

van der Post RS et. al. (2015) Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.

[^]
Update: 8. Mai 2019