Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel

Hepatitis B-Infektionsanfälligkeit

Die Anfälligkeit gegenüber HBV-Infektionen kann durch genetische Varianten im IL10RB-Gen, welches eine Komponente des Interleukin 10-Rezeptors kodiert, vermittelt werden.

Gliederung

Erbliche Lebererkrankungen
Acoeruloplasminämie/Hypocoeruloplasminämie
Budd-Chiari-Syndrom
Caroli Erkrankung
Genetisch bedingte Hyperbilirubinämie
Hepatitis B-Infektionsanfälligkeit
IL10RB
Hepatozelluläres Karzinom
Hämochromatose
Ivemark-Syndrom
Morbus Fabry
Polyzystische Lebererkrankung

Referenzen:

1.

Frodsham AJ et. al. (2006) Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

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2.

Thio CL et al. (2005) Mannose binding lectin genotypes influence recovery from hepatitis B virus infection.

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3.

Kim YJ et al. (2003) Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection.

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4.

Almarri A et. al. (1994) HLA and hepatitis B infection.

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5.

Thursz MR et. al. (1997) Heterozygote advantage for HLA class-II type in hepatitis B virus infection.

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6.

None (2001) Virology. The X files--one step closer to closure.

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7.

Bouchard MJ et. al. (2001) Calcium signaling by HBx protein in hepatitis B virus DNA replication.

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8.

Thio CL et. al. (2004) Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.

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9.

Shepard CW et. al. (2006) Hepatitis B virus infection: epidemiology and vaccination.

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10.

Seeff LB et. al. (2006) Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity.

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11.

Thio CL et. al. (2008) Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B.

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12.

Kamatani Y et. al. (2009) A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.

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13.

Zhou J et. al. (2009) A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.

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14.

Wang J et. al. (2010) CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.

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Update: 8. Mai 2019