Suszeptibilität für Rheumatoide Arthritis

Plenge RM et. al. (2007) TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

Lard LR et. al. (2003) Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.

Robinson JI et. al. (2012) Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.

Nabozny GH et. al. (1996) HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis.

Bradley DS et. al. (1997) HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis.

Kawane K et al. (2006) Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.

Begovich AB et. al. (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

Carlton VE et. al. (2005) PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.

Kallberg H et. al. (2007) Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.

None (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Mahdi H et. al. (2009) Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.

Vyse TJ et al. (1996) Genetic analysis of autoimmune disease.

Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.

Remmers EF et al. (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

Martínez A et. al. (2008) Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.

et. al. (2010) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Stastny P et. al. (1979) Different HLA-D associations in adult and juvenile rheumatoid arthritis.

Weyand CM et. al. (1992) Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.

Bell AL et. al. (1992) Heredofamilial deficiency of monocyte esterase in patients with rheumatoid arthritis.

Gregersen PK et. al. (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.

Lynn AH et. al. (1995) Genetic epidemiology of rheumatoid arthritis.

Hasstedt SJ et. al. (1994) HLA-linked rheumatoid arthritis.

Feldmann M et. al. (1996) Rheumatoid arthritis.

Nanki T et. al. (1996) Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins.

Vingsbo C et. al. (1996) Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes.

Cornélis F et. al. (1998) New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study.

Vingsbo-Lundberg C et. al. (1998) Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats.

Cox A et. al. (1999) Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis.

Müller-Ladner U et. al. (2000) Activation of the IL-4 STAT pathway in rheumatoid synovium.

Zanelli E et. al. (2001) The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci.

Ota M et. al. (2001) A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region.

Allcock RJ et. al. (2001) Haplotypic single nucleotide polymorphisms in the central MHC gene IKBL, a potential regulator of NF-kappaB function.

Holm BC et. al. (2001) Rats made congenic for Oia3 on chromosome 10 become susceptible to squalene-induced arthritis.

Jawaheer D et. al. (2001) A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases.

Yen JH et. al. (2001) Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis.

Schaller M et. al. (2001) Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease.

Barton A et. al. (2001) High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis.

Jawaheer D et. al. (2002) Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis.

Okamoto K et. al. (2003) Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.

Nedvetzki S et. al. (2003) A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor.

Fisher SA et. al. (2003) Meta-analysis of four rheumatoid arthritis genome-wide linkage studies: confirmation of a susceptibility locus on chromosome 16.

Suzuki A et. al. (2003) Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.

Hill JA et. al. (2003) Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule.

GOWANS JD et. al. (1964) FAMILIAL FACTORS IN RHEUMATOID ARTHRITIS.

Vandenbroeck K et. al. (2003) Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis.

Schönland SO et. al. (2003) Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.

Tokuhiro S et. al. (2003) An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.

Sakaguchi N et. al. (2003) Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice.

John S et. al. (2004) Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites.

Seo SK et. al. (2004) 4-1BB-mediated immunotherapy of rheumatoid arthritis.

Lundberg K et. al. (2005) Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity.

Tamiya G et. al. (2005) Whole genome association study of rheumatoid arthritis using 27 039 microsatellites.

Camps M et. al. (2005) Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Seyler TM et. al. (2005) BLyS and APRIL in rheumatoid arthritis.

Amos CI et. al. (2006) High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33.

Rizzo R et. al. (2006) HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis.

Sigurdsson S et. al. (2007) Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.

Thomson W et. al. (2007) Rheumatoid arthritis association at 6q23.

Plenge RM et. al. (2007) Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Raychaudhuri S et. al. (2008) Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

Suzuki A et. al. (2008) Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population.

Barton A et. al. (2009) Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

Orozco G et. al. (2009) Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.

Gregersen PK et. al. (2009) REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

Raychaudhuri S et. al. (2009) Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Boilard E et. al. (2010) Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.

Kochi Y et. al. (2010) A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.

Stahl EA et. al. (2010) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Kurreeman F et. al. (2011) Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.

Okada Y et. al. (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Raj T et. al. (2014) Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.

Ito Y et. al. (2014) Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.