Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Präeklampsie

Die Präeklampsie ist eine Erkrankung der Schwangerschaft. Nach der 20. Schwangerschaftswoche kommt es es zu einem Blutdruckanstieg und zu einer Proteinurie. Im weiteren Verlauf kann sich die Erkrankung in eine lebensbedrohliche Situation (Eklampsie) entwickeln. Ursächlich scheinen genetische Faktoren und auch STörungen der Komplementregulation eine Rolle zu spielen.

Gliederung

Erblicher Bluthochdruck
ACE
ACE2
AGT
Benigne Hyperproreninämie
Monogener Hypertonus
Präeklampsie
APOL1
Präeklampsie 1
Präeklampsie 2
Präeklampsie 3
Präeklampsie 4
STOX1
Präeklampsie 5
CORIN
Salzsensitiver essentieller Hypertonus
VEGFC

Referenzen:

1.

None (2003) The genetics of pre-eclampsia: a feto-placental or maternal problem?

external link
2.

Rajkovic A et al. (2000) Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe.

external link
3.

Napolitano M et al. (2000) Expression and relationship between endothelin-1 messenger ribonucleic acid (mRNA) and inducible/endothelial nitric oxide synthase mRNA isoforms from normal and preeclamptic placentas.

external link
4.

Page NM et al. (2000) Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.

external link
5.

Brown MA et al. (2000) The detection, investigation and management of hypertension in pregnancy: full consensus statement.

external link
6.

Moses EK et al. (2000) A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2.

external link
7.

Roberts JM et al. (2001) Pathogenesis and genetics of pre-eclampsia.

external link
8.

Esplin MS et al. (2001) Paternal and maternal components of the predisposition to preeclampsia.

external link
9.

Zusterzeel PL et al. (2001) A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia.

external link
10.

Lachmeijer AM et al. (2001) A genome-wide scan for preeclampsia in the Netherlands.

external link
11.

Zusterzeel PL et al. (2002) Paternal contribution to the risk for pre-eclampsia.

external link
12.

Laasanen J et al. (2002) Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia.

external link
13.

Maynard SE et al. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.

external link
14.

Wallukat G et al. (1999) Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.

external link
15.

Faisel F et al. (2004) Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation.

external link
16.

Levine RJ et al. (2004) Circulating angiogenic factors and the risk of preeclampsia.

external link
17.

Cnattingius S et al. (2004) Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study.

external link
18.

None (2005) Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study.

external link
19.

Uz E et al. (2007) Extremely skewed X-chromosome inactivation is increased in pre-eclampsia.

external link
20.

Kanasaki K et al. (2008) Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.

external link
21.

Berends AL et al. (2008) Familial aggregation of preeclampsia and intrauterine growth restriction in a genetically isolated population in The Netherlands.

external link
22.

Zhou CC et al. (2008) Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice.

external link
23.

Payne B et al. (2011) Assessment, surveillance and prognosis in pre-eclampsia.

external link
24.

Uzan J et al. (2011) Pre-eclampsia: pathophysiology, diagnosis, and management.

external link
25.

van Dijk M et al. (2012) HELLP babies link a novel lincRNA to the trophoblast cell cycle.

external link
26.

Oudejans CB et al. (2015) Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia.

external link
27.

Arngrímsson R et al. (1999) A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13.

external link
28.

Hillermann R et al. (2005) The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia.

external link
29.

Hiby SE et al. (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success.

external link
30.

Reidy KJ et al. (2018) Fetal-Not Maternal-APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry.

external link
31.

Dries DL et al. (2005) Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.

external link
32.

Wang W et al. (2008) Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.

external link
33.

Dong N et al. (2013) Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.

external link
34.

Pan J et al. (2002) Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.

external link
35.

Knappe S et al. (2003) Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.

external link
36.

Guipponi M et al. (2008) An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.

external link
37.

Cui Y et al. (2012) Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.

external link
38.

Dong N et al. (2014) Corin mutations K317E and S472G from preeclamptic patients alter zymogen activation and cell surface targeting. [Corrected].

external link
39.

Laivuori H et al. (2003) Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families.

external link
40.

Chesley LC et al. (1968) The familial factor in toxemia of pregnancy.

external link
41.

None (1980) Genetic control of pre-eclampsia.

external link
42.

Fisher KA et al. (1981) Hypertension in pregnancy: clinical-pathological correlations and remote prognosis.

external link
43.

Van Meter TD et al. (1993) Concerns about the genetics of pre-eclampsia.

external link
44.

Brenner B et al. (1996) HELLP syndrome associated with factor V R506Q mutation.

external link
45.

Harrison GA et al. (1997) A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q.

external link
46.

Sohda S et al. (1997) Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia.

external link
47.

Arngrímsson R et al. (1997) Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region.

external link
48.

Lindqvist PG et al. (1998) Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism.

external link
49.

Kupferminc MJ et al. (1999) Increased frequency of genetic thrombophilia in women with complications of pregnancy.

external link
50.

Thornton JG et al. (1999) Twin mothers, pregnancy hypertension and pre-eclampsia.

external link
51.

Zusterzeel PL et al. (1999) Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies.

external link
52.

Orphanet article

Orphanet ID 275555 external link
53.

Wikipedia Artikel

Wikipedia DE (Eklampsie) external link
Update: 14. August 2020
Copyright © 2005-2020 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz