Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Atopie

Unter Atopie wird eine angeborene Überempfindlichkeitsreaktion gegenüber verschiedenen chemischen Stoffen verstanden. Die Reaktion ist IgE-vermittelt und kann an allen Kontaktflächen auftreten (Haut, Magen-Darm-Trakt, Atemwege).

Gliederung

Erbliche immunologische Erkrankungen
Atopie
MS4A2
Chronisch entzündliche Störungen
Erbliche Complementstörungen
Neigung zu Asthma bronchiale
Neigung zu allergischer Rhinitis
Primärer Immundefekt
Störungen der Immunglobulinbildung

Referenzen:

1.

Hizawa N et. al. (1995) Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects.

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2.

Sandford AJ et. al. (1993) Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.

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3.

Shin HD et. al. (2004) Association of tumor necrosis factor polymorphisms with asthma and serum total IgE.

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4.

Lympany P et. al. (1992) Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine.

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5.

Amelung PJ et. al. (1992) Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p.

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6.

Palmer LJ et. al. (2000) Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families.

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7.

Moffatt MF et. al. (2001) Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample.

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8.

Anderson GG et. al. (2002) Positive association to IgE levels and a physical map of the 13q14 atopy locus.

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9.

Zhang Y et. al. (2003) Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

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10.

Shin HD et. al. (2003) Association of Eotaxin gene family with asthma and serum total IgE.

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11.

Hysi P et. al. (2005) NOD1 variation, immunoglobulin E and asthma.

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12.

Bottazzo GF et. al. (1976) Separate autoantibodies to human pancreatic glucagon and somatostatin cells.

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13.

Gerrard JW et. al. (1978) A genetic study of immunoglobulin E.

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14.

Marsh DG et. al. (1992) A major gene for allergy--fact or fancy?

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15.

Cookson WO et. al. (1992) Maternal inheritance of atopic IgE responsiveness on chromosome 11q.

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16.

None (1992) John Bostock, hay fever, and the mechanism of allergy.

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17.

Lympany P et. al. (1992) Genetic analysis of the linkage between chromosome 11q and atopy.

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18.

Moffatt MF et. al. (1992) Factors confounding genetic linkage between atopy and chromosome 11q.

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19.

Hizawa N et. al. (1992) Lack of linkage between atopy and locus 11q13.

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20.

Rich SS et. al. (1992) Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97.

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21.

None (1992) Genetic linkage: interpreting lod scores.

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22.

Young RP et. al. (1992) Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13.

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23.

Hanson B et. al. (1991) Atopic disease and immunoglobulin E in twins reared apart and together.

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24.

Cookson WO et. al. (1989) Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.

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25.

Cookson WO et. al. (1988) Dominant inheritance of atopic immunoglobulin-E responsiveness.

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26.

Jeffreys AJ et. al. () Hypervariable 'minisatellite' regions in human DNA.

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27.

Marsh DG et. al. (1974) Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity.

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28.

Morton NE et. al. (1974) Analysis of family resemblance. 3. Complex segregation of quantitative traits.

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29.

None (1972) Emperic risks for genetic counseling in families with allergy.

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30.

Meyers DA et. al. (1983) The inheritance of immunoglobulin E: genetic linkage analysis.

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31.

Hasstedt SJ et. al. (1983) Inheritance of immunoglobulin E: genetic model fitting.

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32.

Blumenthal MN et. al. (1981) Genetic transmission of serum IgE Levels.

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33.

Rao DC et. al. (1980) Immunoglobulin E revisited.

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34.

Shirakawa T et. al. (1994) Linkage between severe atopy and chromosome 11q13 in Japanese families.

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35.

Coleman R et. al. (1993) Chromosome 11q13 and atopy underlying atopic eczema.

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36.

Collée JM et. al. (1993) Allele sharing on chromosome 11q13 in sibs with asthma and atopy.

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37.

Kimura K et. al. (1999) Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population.

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38.

Oettgen HC et. al. (1999) IgE in asthma and atopy: cellular and molecular connections.

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39.

Milgrom H et. al. (1999) Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group.

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40.

Wheatley AP et. al. (2002) Identification of the autoantigen SART-1 as a candidate gene for the development of atopy.

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41.

Hargrave S et. al. (2003) Preliminary findings in corneal allograft rejection in patients with keratoconus.

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42.

Hecker M et. al. (2003) Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females.

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43.

None (1954) A study of the inheritance of atopic hypersensitivity in man.

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44.

None (1960) Prurigo Besnier (atopic dermatitis) with special reference to the role of allergic factors. I. The influence of atopic hereditary factors.

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45.

Sharma S et. al. (2005) A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels.

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46.

Mathias RA et. al. (2005) Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses.

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Update: 26. September 2018

 

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