Einige genetische Varianten im GDF5-Gen scheinen mit einer Osteoarthritis insbesondere im Hüftgelenk assoziiert zu sein.
1. |
Miyamoto Y et al. (2007) A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. |
2. |
Masuya H et al. (2007) A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice. |
3. |
Dodd AW et al. (2013) A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression. |
4. |
OMIM.ORG article Omim 612400 |