Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Hereditäres papilläres Nierenzellkarzinom 1

Das familiäre papilläre Nierenzellkarzinom vom Typ 1 wird durch Keimbahn-Mutatioen im MET-Gen hervorgerufen. Es die Erkrankung ist eine Disposition für Mulilokuläre Ausbildung solcher Karzinome. Bei nicht familiären Formen lassen sich gelegentlich auch somatische Mutationen im MET-Gen nachweisen.

Gliederung

Hereditäres papilläres Nierenzellkarzinom
Hereditäres papilläres Nierenzellkarzinom 1
MET
PRCC

Referenzen:

1.

Schmidt L et. al. (1997) Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.

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2.

Zhuang Z et. al. (1998) Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.

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3.

Cohen AJ et. al. (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation.

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4.

Cohen HT et. al. (2005) Renal-cell carcinoma.

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5.

Bodmer D et. al. (2002) Understanding familial and non-familial renal cell cancer.

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6.

Kuiper RP et. al. (2003) Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution.

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7.

Kovacs G et. al. (1997) The Heidelberg classification of renal cell tumours.

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8.

Mancilla-Jimenez R et. al. (1976) Papillary renal cell carcinoma: a clinical, radiologic, and pathologic study of 34 cases.

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9.

Kovacs G et. al. (1991) Cytogenetics of papillary renal cell tumors.

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10.

Zbar B et. al. (1995) Hereditary papillary renal cell carcinoma: clinical studies in 10 families.

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11.

None (1993) Molecular cytogenetics of renal cell tumors.

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12.

Zbar B et. al. (1994) Hereditary papillary renal cell carcinoma.

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13.

Fischer J et. al. (1998) Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours.

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14.

Balint I et. al. (1999) Mapping the papillary renal cell carcinoma gene between loci D17S787 and D17S1799 on chromosome 17q21.32.

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15.

Kuroda N et. al. (2003) Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.

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16.

Yang XJ et. al. (2005) A molecular classification of papillary renal cell carcinoma.

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17.

None (2011) Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics.

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Update: 28. März 2018