Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Hepatozelluläres Karzinom

Das hepatozelluläres Karzinom der Kindheit wird durch somatische Mutationen im MET-Gen ausgelöst.

Gliederung

Erbliche Lebererkrankungen
Acoeruloplasminämie/Hypocoeruloplasminämie
Budd-Chiari-Syndrom
Caroli Erkrankung
Genetisch bedingte Hyperbilirubinämie
Hepatitis B-Infektionsanfälligkeit
Hepatozelluläres Karzinom
MET
Hämochromatose
Ivemark-Syndrom
Morbus Fabry
Polyzystische Lebererkrankung
Trichohepatoenterisches Syndrom

Referenzen:

1.

Tanabe KK et al. (2008) Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.

external link
2.

McGlynn KA et al. (1995) Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.

external link
3.

Oda H et al. (1996) Somatic mutations of the APC gene in sporadic hepatoblastomas.

external link
4.

Agarwal VR et al. (1998) Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.

external link
5.

Schwienbacher C et al. (2000) Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas.

external link
6.

Taniguchi K et al. (2002) Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.

external link
7.

Thorgeirsson SS et al. (2002) Molecular pathogenesis of human hepatocellular carcinoma.

external link
8.

Ye QH et al. (2003) Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning.

external link
9.

KAPLAN L et al. (1965) FRATERNAL PRIMARY HEPATOCELLULAR CARCINOMA IN THREE MALE, ADULT SIBLINGS.

external link
10.

Lee JW et al. (2005) PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

external link
11.

Chiu CM et al. (2007) Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level.

external link
12.

Yong KJ et al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

external link
13.

Yoo BK et al. (2009) Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression.

external link
14.

Hill-Baskin AE et al. (2009) Diet-induced hepatocellular carcinoma in genetically predisposed mice.

external link
15.

Yoo BK et al. (2009) Identification of genes conferring resistance to 5-fluorouracil.

external link
16.

Ji J et al. (2009) MicroRNA expression, survival, and response to interferon in liver cancer.

external link
17.

Zhang H et al. (2010) Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.

external link
18.

Kumar V et al. (2011) Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.

external link
19.

Li M et al. (2011) Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.

external link
20.

Huang J et al. (2012) Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma.

external link
21.

Honeyman JN et al. (2014) Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.

external link
22.

Lynch HT et al. (1984) Familial hepatocellular carcinoma in an endemic area of Thailand.

external link
23.

Shin HD et. al. (2003) Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.

external link
24.

Hopkins LJ et al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

external link
25.

Suzuki E et al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

external link
26.

Masuda S et al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

external link
27.

Kishnani PS et al. (2009) Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ia glycogen storage disease.

external link
28.

Napoli VM et al. (1977) Hepatoblastoma in infant sister and brother.

external link
29.

Shen FM et al. (1991) Complex segregation analysis of primary hepatocellular carcinoma in Chinese families: interaction of inherited susceptibility and hepatitis B viral infection.

external link
30.

Buetow KH et al. (1989) Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.

external link
31.

Pasquinelli C et al. (1988) Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

external link
32.

Henderson AS et al. (1988) Identification of a chromosomal aberration associated with a hepatitis B DNA integration site in human cells.

external link
33.

Zhou YZ et al. (1988) Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma.

external link
34.

Blanquet V et al. (1988) Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer.

external link
35.

Wang HP et al. (1988) Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas.

external link
36.

Rogler CE et al. (1985) Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma.

external link
37.

Fisher JH et al. (1987) Sequences which flank an 11p deletion observed in an hepatocellular carcinoma map to 11p13.

external link
38.

Ito E et al. (1987) Type 1a glycogen storage disease with hepatoblastoma in siblings.

external link
39.

Hagstrom RM et al. (1968) Primary hepatocellular carcinoma in three male siblings.

external link
40.

Fraumeni JF et al. (1969) Hepatoblastoma in infant sisters.

external link
41.

Denison EK et al. (1971) Familial hepatoma with hepatitis-associated antigen.

external link
42.

Chang MH et al. (1984) Fraternal hepatocellular carcinoma in young children in two families.

external link
43.

OMIM.ORG article

Omim 114550 external link
44.

Orphanet article

Orphanet ID 88673 external link
Update: 14. August 2020
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