Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Hepatozelluläres Karzinom

Das hepatozelluläres Karzinom der Kindheit wird durch somatische Mutationen im MET-Gen ausgelöst.

Gliederung

Erbliche Lebererkrankungen
Acoeruloplasminämie/Hypocoeruloplasminämie
Caroli Erkrankung
Genetisch bedingte Hyperbilirubinämie
Hepatozelluläres Karzinom
MET
Hämochromatose
Ivemark-Syndrom
Morbus Fabry
Polyzystische Lebererkrankung

Referenzen:

1.

Yong KJ et. al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

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2.

Hopkins LJ et. al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

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3.

Suzuki E et. al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

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4.

Masuda S et. al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

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5.

Kishnani PS et. al. (2009) Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ia glycogen storage disease.

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6.

Napoli VM et. al. (1977) Hepatoblastoma in infant sister and brother.

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7.

Shen FM et. al. (1991) Complex segregation analysis of primary hepatocellular carcinoma in Chinese families: interaction of inherited susceptibility and hepatitis B viral infection.

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8.

Buetow KH et. al. (1989) Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.

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9.

Pasquinelli C et. al. (1988) Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

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10.

Henderson AS et. al. (1988) Identification of a chromosomal aberration associated with a hepatitis B DNA integration site in human cells.

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11.

Zhou YZ et. al. (1988) Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma.

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12.

Blanquet V et. al. (1988) Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer.

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13.

Wang HP et. al. (1988) Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas.

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14.

Rogler CE et. al. (1985) Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma.

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15.

Fisher JH et. al. (1987) Sequences which flank an 11p deletion observed in an hepatocellular carcinoma map to 11p13.

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16.

Ito E et. al. (1987) Type 1a glycogen storage disease with hepatoblastoma in siblings.

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17.

Hagstrom RM et. al. (1968) Primary hepatocellular carcinoma in three male siblings.

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18.

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19.

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20.

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21.

Chang MH et. al. (1984) Fraternal hepatocellular carcinoma in young children in two families.

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22.

McGlynn KA et. al. (1995) Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.

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23.

Oda H et. al. (1996) Somatic mutations of the APC gene in sporadic hepatoblastomas.

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24.

Agarwal VR et. al. (1998) Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma.

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25.

Schwienbacher C et. al. (2000) Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas.

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26.

Taniguchi K et. al. (2002) Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.

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27.

Thorgeirsson SS et. al. (2002) Molecular pathogenesis of human hepatocellular carcinoma.

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28.

Ye QH et. al. (2003) Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning.

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29.

Shin HD et. al. (2003) Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma.

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30.

KAPLAN L et. al. (1965) FRATERNAL PRIMARY HEPATOCELLULAR CARCINOMA IN THREE MALE, ADULT SIBLINGS.

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31.

Lee JW et. al. (2005) PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

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32.

Chiu CM et. al. (2007) Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level.

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33.

Tanabe KK et. al. (2008) Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.

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34.

Yoo BK et. al. (2009) Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression.

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35.

Hill-Baskin AE et. al. (2009) Diet-induced hepatocellular carcinoma in genetically predisposed mice.

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36.

Yoo BK et. al. (2009) Identification of genes conferring resistance to 5-fluorouracil.

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37.

Ji J et. al. (2009) MicroRNA expression, survival, and response to interferon in liver cancer.

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38.

Zhang H et. al. (2010) Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.

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39.

Kumar V et. al. (2011) Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.

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40.

Li M et. al. (2011) Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.

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41.

Huang J et. al. (2012) Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma.

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42.

Honeyman JN et. al. (2014) Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.

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Update: 28. März 2018