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Somatisches Nephroblastom

Der Wilms-Tumor (Nephroblastom) kann auch durch somatische Mutationen in den Genen GPC3, WT1 und BRCA2 ausgelöst werden.

Gliederung

Wilms-Tumor
Aniridie-Wilms-Tumor-Syndrom
Denys-Drash-Syndrom
Somatisches Nephroblastom
GPC3
WT1
WAGR-Syndrom

Referenzen:

1.

Yunis JJ et al. (1980) Familial occurrence of the aniridia-Wilms tumor syndrome with deletion 11p13-14.1.

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2.

Fearon ER et al. () Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.

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3.

Reeve AE et al. () Loss of a Harvey ras allele in sporadic Wilms' tumour.

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4.

Orkin SH et al. () Development of homozygosity for chromosome 11p markers in Wilms' tumour.

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5.

Koufos A et al. () Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.

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6.

de Martinville B et al. () The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour.

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7.

Huerre C et al. () c-Ha-ras1 is not deleted in aniridia-Wilms' tumour association.

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8.

McCoy FE et al. (1983) Glomerulonephritis associated with male pseudohermaphroditism and nephroblastoma.

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9.

Breslow NE et al. (1982) Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study.

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10.

Kaneko Y et al. (1981) Interstitial deletion of short arm of chromosome 11 limited to Wilms' tumor cells in a patient without aniridia.

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11.

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12.

Cordero JF et al. (1980) Wilms tumor in five cousins.

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13.

Nordenskjöld A et al. (1995) Absence of mutations in the WT1 gene in patients with XY gonadal dysgenesis.

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None (1980) Genes and cancer: the story of Wilms tumor.

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16.

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18.

Ladda R et al. (1974) Computer-assisted analysis of chromosomal abnormalities: detection of a deletion in aniridia-Wilms' tumor syndrome.

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19.

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20.

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21.

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23.

Fraumeni JF et al. (1968) Wilms' tumor and congenital aniridia.

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24.

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25.

Patek CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.

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26.

Royer-Pokora B et al. (2010) Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.

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27.

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28.

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29.

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39.

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40.

Miyagawa K et al. (1998) Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour.

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41.

Schumacher V et al. (1997) Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology.

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42.

Rahman N et al. (1996) Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21.

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43.

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44.

Park S et al. (1993) Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.

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45.

Park S et al. (1993) Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour.

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46.

Haber DA et al. (1993) WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

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47.

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48.

Haber DA et al. (1992) A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.

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49.

White GR et al. (2002) Somatic glypican 3 (GPC3) mutations in Wilms' tumour.

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50.

Kozman HM et al. (1989) Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor.

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51.

Kumar S et al. (1987) A cell line from Wilms' tumour with deletion in short arm of chromosome II.

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52.

Haber DA et al. (1990) An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.

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53.

None (1990) Molecular genetics. A gene for Wilms tumour?

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54.

van Heyningen V et al. (1990) Role for the Wilms tumor gene in genital development?

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55.

Jeanpierre C et al. (1990) Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.

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56.

Huff V et al. (1990) Parental origin of de novo constitutional deletions of chromosomal band 11p13.

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57.

Schwartz CE et al. (1991) Familial predisposition to Wilms tumor does not segregate with the WT1 gene.

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58.

Kakati S et al. (1991) Constitutional extra chromosomal element in a family with Wilms' tumor.

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59.

Ton CC et al. (1991) Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.

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60.

de Ronde A et al. (1988) Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11.

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61.

Dressler GR et al. (1992) Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

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62.

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63.

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64.

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65.

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66.

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67.

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68.

Narahara K et al. (1984) Regional mapping of catalase and Wilms tumoraniridia, genitourinary abnormalities, and mental retardation triad loci to the chromosome segment 11p1305--p1306.

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69.

Turleau C et al. (1984) Del11p13/nephroblastoma without aniridia.

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70.

Rivera MN et al. (2007) An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.

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71.

Scoggin CH et al. (1985) The E7-associated cell-surface antigen: a marker for the 11p13 chromosomal deletion associated with aniridia-Wilms tumor.

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72.

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73.

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74.

Kaufman RL et al. (1973) Wilms' tumour in father and son.

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75.

None (1986) Chromosomal deletions and enzyme deficiencies.

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76.

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77.

Kinberg JA et al. (1987) Nephropathy-gonadal dysgenesis, type 2: renal failure in three siblings with XY dysgenesis in one.

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78.

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79.

Porteous DJ et al. (1987) HRAS1-selected chromosome transfer generates markers that colocalize aniridia- and genitourinary dysplasia-associated translocation breakpoints and the Wilms tumor gene within band 11p13.

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80.

Weissman BE et al. (1987) Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression.

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81.

van Heyningen V et al. (1985) Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome.

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82.

Seawright A et al. (1988) Analysis of WAGR deletions and related translocations with gene-specific DNA probes, using FACS-selected cell hybrids.

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83.

Scott J et al. () Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.

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84.

Reeve AE et al. () Expression of insulin-like growth factor-II transcripts in Wilms' tumour.

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85.

Koufos A et al. () Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.

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86.

Raizis AM et al. (1985) A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13.

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87.

Michalopoulos EE et al. (1985) Molecular analysis of gene deletion in aniridia--Wilms tumor association.

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88.

Schroeder WT et al. (1987) Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.

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89.

Mannens M et al. (1988) Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours.

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90.

Huff V et al. (1988) Lack of linkage of familial Wilms' tumour to chromosomal band 11p13.

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91.

Grundy P et al. (1988) Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11.

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92.

Puissant H et al. (1988) Molecular analysis of a reciprocal translocation t(5;11) (q11;p13) in a WAGR patient.

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93.

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Update: 14. August 2020
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