Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Schilddrüsenkarzinome

Schilddrüsenkarzinome betreffen vor allem (95%) die folikulären Zellen, die für die Sekretion des Schilddrüsenhormons zuständig sind. Der Rest entwickelt sich aus parafolikulären, medullären Zellen, die das Calcitonin produzieren. Mutationen können als Keimbahn- oder somatische Mutationen vorkommen.

Gliederung

Störungen des Schilddrüsenhormonsystems
Dysalbuminämische Hyperthyroxinämie
Hyperthyreose
Hypothyreose
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen
Schilddrüsenhormonresistenz
Schilddrüsenkarzinome
Familiäres meduläres Schilddrüsenkarzinom
NTRK1
RET
Nicht-medulläres Schilddrüsenkarzinom
Autonomes Schilddrüsenadenom
TSHR
Familiäres folliculäres Schilddrüsenkarzinom
MINPP1
Folliculäres Schilddrüsenkarzinom
HRAS
NRAS
Nicht-medulläres Schilddrüsenkarzinom 1
NKX2-1
Nicht-medulläres Schilddrüsenkarzinom 2
SRGAP1
Nicht-medulläres Schilddrüsenkarzinom 3
Nicht-medulläres Schilddrüsenkarzinom 4
FOXE1
Nicht-medulläres Schilddrüsenkarzinom 5
HABP2
Schilddrüsenkarzinom mit Thyreotoxikose
TSHR

Referenzen:

1.

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2.

Chua EL et al. (2000) Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia.

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3.

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4.

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25.

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30.

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34.

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35.

Klugbauer S et al. (1999) The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.

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42.

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43.

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44.

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45.

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46.

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47.

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48.

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49.

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50.

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51.

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52.

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53.

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54.

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55.

Learoyd DL et al. (1998) RET/PTC and RET tyrosine kinase expression in adult papillary thyroid carcinomas.

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56.

Sugg SL et al. (1998) Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia.

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57.

Canzian F et al. (1998) A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2.

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58.

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59.

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60.

Thomas GA et al. (1999) High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.

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Update: 14. August 2020
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