Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Salzsensitiver essentieller Hypertonus

Die Neigung zur Entwicklung eines salzsensitiven essentiellen Hypertonus ist mit genetschen Variationen verknüpft.

Gliederung

Erblicher Bluthochdruck
ACE
ACE2
AGT
Benigne Hyperproreninämie
Monogener Hypertonus
Präeklampsie
Salzsensitiver essentieller Hypertonus
CYP3A5
VEGFC

Referenzen:

1.

None (1996) Molecular genetics of human blood pressure variation.

external link
2.

Xu X et al. (1999) An extreme-sib-pair genome scan for genes regulating blood pressure.

external link
3.

Siffert W et al. (1998) Association of a human G-protein beta3 subunit variant with hypertension.

external link
4.

Tanaka M et al. (1997) Genetically determined chloride-sensitive hypertension and stroke.

external link
5.

Vincent M et al. (1997) A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.

external link
6.

Churchill PC et al. (1997) Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.

external link
7.

Chiang FT et al. (1997) Association of the renin gene polymorphism with essential hypertension in a Chinese population.

external link
8.

Noon JP et al. (1997) Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure.

external link
9.

Pietruck F et al. (1996) Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.

external link
10.

Frossard PM et al. (1995) Association between a dimorphic site on chromosome 12 and clinical diagnosis of hypertension in three independent populations.

external link
11.

Wu DA et al. (1996) Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.

external link
12.

Baima J et al. (1999) Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.

external link
13.

Gu L et al. (1996) Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.

external link
14.

Brown DM et al. (1996) Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

external link
15.

Kurtz TW et al. (1993) Genetics of essential hypertension.

external link
16.

Edwards CR et al. (1993) Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?

external link
17.

Benediktsson R et al. (1993) Glucocorticoid exposure in utero: new model for adult hypertension.

external link
18.

Deng AY et al. (1994) Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

external link
19.

Dubay C et al. (1993) Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.

external link
20.

Cicila GT et al. (1993) Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat.

external link
21.

Siffert W et al. (1995) Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension.

external link
22.

Kreutz R et al. (1995) Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

external link
23.

None (1963) Heredity in hypertension.

external link
24.

Deo RC et al. (2007) A high-density admixture scan in 1,670 African Americans with hypertension.

external link
25.

Rutherford S et al. (2007) A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.

external link
26.

Chang YP et al. (2007) Multiple genes for essential-hypertension susceptibility on chromosome 1q.

external link
27.

Guzmán B et al. (2006) Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.

external link
28.

Wallace C et al. (2006) Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.

external link
29.

Zhu X et al. (2005) Admixture mapping for hypertension loci with genome-scan markers.

external link
30.

Gainer JV et al. (2005) Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

external link
31.

Koivukoski L et al. (2004) Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3.

external link
32.

Rutherford S et al. (2004) Sibpair studies implicate chromosome 18 in essential hypertension.

external link
33.

MCDONOUGH JR et al. (1964) BLOOD PRESSURE AND HYPERTENSIVE DISEASE AMONG NEGROES AND WHITES; A STUDY IN EVANS COUNTY, GEORGIA.

external link
34.

Bonnardeaux A et al. (1994) Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

external link
35.

DAHL LK et al. (1962) Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension.

external link
36.

Funke-Kaiser H et al. (2003) Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation.

external link
37.

Nakayama T et al. (2002) Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.

external link
38.

Angius A et al. (2002) A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search.

external link
39.

Yamamoto N et al. (2002) Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension.

external link
40.

Rutherford S et al. (2001) Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension.

external link
41.

Lifton RP et al. (2001) Molecular mechanisms of human hypertension.

external link
42.

Glenn CL et al. (2000) Linkage and association of tumor necrosis factor receptor 2 locus with hypertension, hypercholesterolemia and plasma shed receptor.

external link
43.

Garbers DL et al. (1999) The molecular basis of hypertension.

external link
44.

Garay RP et al. (1979) A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients.

external link
45.

None (1990) Inheritance of hypertension and blood pressure reactivity.

external link
46.

Ravogli A et al. (1990) Early 24-hour blood pressure elevation in normotensive subjects with parental hypertension.

external link
47.

Pérusse L et al. (1991) Evidence that a single gene with gender- and age-dependent effects influences systolic blood pressure determination in a population-based sample.

external link
48.

None (1991) Blood pressure control--special role of the kidneys and body fluids.

external link
49.

Rebbeck TR et al. (1991) Genetic and environmental explanations for the distribution of sodium-lithium countertransport in pedigrees from Rochester, MN.

external link
50.

Lifton RP et al. (1991) Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension.

external link
51.

Parmer RJ et al. (1992) Baroreflex sensitivity and heredity in essential hypertension.

external link
52.

Hilbert P et al. (1991) Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.

external link
53.

Jacob HJ et al. (1991) Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.

external link
54.

None (1978) Normotension and hypertension: the mysterious viability of the false.

external link
55.

Trippodo NC et al. (1981) Similarities of genetic (spontaneous) hypertension. Man and rat.

external link
56.

Gong M et al. (2003) Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p.

external link
57.

Dong N et al. (2013) Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.

external link
58.

Wang W et al. (2008) Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.

external link
59.

Dries DL et al. (2005) Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.

external link
60.

Machnik A et al. (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.

external link
61.

Rapp JP et al. (1989) A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure.

external link
62.

van Hooft IM et al. (1991) Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents.

external link
63.

Zhang Y et al. (2004) D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients.

external link
64.

Julier C et al. (1997) Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.

external link
65.

Caulfield M et al. (1994) Linkage of the angiotensinogen gene to essential hypertension.

external link
66.

None (1985) MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

external link
67.

None (1995) Heterogeneous hypertension.

external link
68.

None (1980) Hypertension and the red cell.

external link
69.

Canessa M et al. (1980) Increased sodium-lithium countertransport in red cells of patients with essential hypertension.

external link
70.

Garay RP et al. (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes.

external link
71.

Ibsen KK et al. () Essential hypertension: sodium-lithium countertransport in erythrocytes from patients and from children having one hypertensive parent.

external link
72.

Etkin NL et al. (1982) Racial differences in hypertension-associated red cell sodium permeability.

external link
73.

Woods JW et al. (1982) Increased red-cell sodium-lithium countertransport in normotensive sons of hypertensive parents.

external link
74.

Woods JW et al. (1983) Perturbation of sodium-lithium countertransport in red cells.

external link
75.

Woods KL et al. (1981) Familial abnormality of erythrocyte cation transport in essential hypertension.

external link
76.

De Mendonca M et al. (1980) Abnormal net Na+ and K+ fluxes in erythrocytes of three varieties of genetically hypertensive rats.

external link
77.

Garay RP et al. (1980) Inherited defect in a Na+, K-co-transport system in erythrocytes from essential hypertensive patients.

external link
78.

None (1983) Genetics, environment, and hypertension.

external link
79.

Clegg G et al. (1982) The heterogeneity of essential hypertension. Relation between lithium efflux and sodium content of erythrocytes and a family history of hypertension.

external link
80.

de Wardener HE et al. (1982) The natriuretic hormone and essential hypertension.

external link
81.

Parfrey PS et al. (1981) Blood pressure and hormonal changes following alteration in dietary sodium and potassium in young men with and without a familial predisposition to hypertension.

external link
82.

Kurtz TW et al. (1985) Hypertension in the recently weaned Dahl salt-sensitive rat despite a diet deficient in sodium chloride.

external link
83.

None (1986) Red-cell lithium-sodium countertransport and renal lithium clearance in hypertension.

external link
84.

Hasstedt SJ et al. (1988) The inheritance of intraerythrocytic sodium level.

external link
85.

Hasstedt SJ et al. (1988) Hypertension and sodium-lithium countertransport in Utah pedigrees: evidence for major-locus inheritance.

external link
86.

Kagamimori S et al. (1985) Familial aggregation of red blood cell cation transport systems in Japanese families.

external link
87.

OMIM.ORG article

Omim 145500 external link
Update: 14. August 2020
Copyright © 2005-2020 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz