Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Salzsensitiver essentieller Hypertonus

Die Neigung zur Entwicklung eines salzsensitiven essentiellen Hypertonus ist mit genetschen Variationen verknüpft.

Gliederung

Erblicher Bluthochdruck
ACE
ACE2
AGT
Benigne Hyperproreninämie
Monogener Hypertonus
Salzsensitiver essentieller Hypertonus
CYP3A5
VEGFC

Referenzen:

1.

Caulfield M et. al. (1994) Linkage of the angiotensinogen gene to essential hypertension.

[^]
2.

Bonnardeaux A et. al. (1994) Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

[^]
3.

Julier C et. al. (1997) Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.

[^]
4.

Zhang Y et. al. (2004) D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients.

[^]
5.

van Hooft IM et al. (1991) Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents.

[^]
6.

Rapp JP et. al. (1989) A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure.

[^]
7.

Machnik A et. al. (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.

[^]
8.

Gong M et. al. (2003) Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p.

[^]
9.

Garay RP et. al. (1979) A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients.

[^]
10.

None (1978) Normotension and hypertension: the mysterious viability of the false.

[^]
11.

Jacob HJ et. al. (1991) Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.

[^]
12.

Hilbert P et. al. (1991) Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.

[^]
13.

Parmer RJ et. al. (1992) Baroreflex sensitivity and heredity in essential hypertension.

[^]
14.

Lifton RP et. al. (1991) Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension.

[^]
15.

Rebbeck TR et. al. (1991) Genetic and environmental explanations for the distribution of sodium-lithium countertransport in pedigrees from Rochester, MN.

[^]
16.

None (1991) Blood pressure control--special role of the kidneys and body fluids.

[^]
17.

Pérusse L et. al. (1991) Evidence that a single gene with gender- and age-dependent effects influences systolic blood pressure determination in a population-based sample.

[^]
18.

Ravogli A et. al. (1990) Early 24-hour blood pressure elevation in normotensive subjects with parental hypertension.

[^]
19.

None (1990) Inheritance of hypertension and blood pressure reactivity.

[^]
20.

Kagamimori S et. al. (1985) Familial aggregation of red blood cell cation transport systems in Japanese families.

[^]
21.

None (1985) MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

[^]
22.

Hasstedt SJ et. al. (1988) Hypertension and sodium-lithium countertransport in Utah pedigrees: evidence for major-locus inheritance.

[^]
23.

Hasstedt SJ et. al. (1988) The inheritance of intraerythrocytic sodium level.

[^]
24.

None (1986) Red-cell lithium-sodium countertransport and renal lithium clearance in hypertension.

[^]
25.

Kurtz TW et. al. (1985) Hypertension in the recently weaned Dahl salt-sensitive rat despite a diet deficient in sodium chloride.

[^]
26.

Parfrey PS et. al. (1981) Blood pressure and hormonal changes following alteration in dietary sodium and potassium in young men with and without a familial predisposition to hypertension.

[^]
27.

de Wardener HE et. al. (1982) The natriuretic hormone and essential hypertension.

[^]
28.

Clegg G et. al. (1982) The heterogeneity of essential hypertension. Relation between lithium efflux and sodium content of erythrocytes and a family history of hypertension.

[^]
29.

None (1983) Genetics, environment, and hypertension.

[^]
30.

Garay RP et. al. (1980) Inherited defect in a Na+, K-co-transport system in erythrocytes from essential hypertensive patients.

[^]
31.

De Mendonca M et. al. (1980) Abnormal net Na+ and K+ fluxes in erythrocytes of three varieties of genetically hypertensive rats.

[^]
32.

Woods KL et. al. (1981) Familial abnormality of erythrocyte cation transport in essential hypertension.

[^]
33.

Woods JW et. al. (1983) Perturbation of sodium-lithium countertransport in red cells.

[^]
34.

Woods JW et. al. (1982) Increased red-cell sodium-lithium countertransport in normotensive sons of hypertensive parents.

[^]
35.

Etkin NL et. al. (1982) Racial differences in hypertension-associated red cell sodium permeability.

[^]
36.

Ibsen KK et. al. () Essential hypertension: sodium-lithium countertransport in erythrocytes from patients and from children having one hypertensive parent.

[^]
37.

Garay RP et. al. (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes.

[^]
38.

Canessa M et. al. (1980) Increased sodium-lithium countertransport in red cells of patients with essential hypertension.

[^]
39.

None (1980) Hypertension and the red cell.

[^]
40.

Trippodo NC et. al. (1981) Similarities of genetic (spontaneous) hypertension. Man and rat.

[^]
41.

None (1995) Heterogeneous hypertension.

[^]
42.

Kreutz R et. al. (1995) Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

[^]
43.

Siffert W et. al. (1995) Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension.

[^]
44.

Cicila GT et. al. (1993) Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat.

[^]
45.

Dubay C et. al. (1993) Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.

[^]
46.

Deng AY et. al. (1994) Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

[^]
47.

Benediktsson R et. al. (1993) Glucocorticoid exposure in utero: new model for adult hypertension.

[^]
48.

Edwards CR et. al. (1993) Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?

[^]
49.

Kurtz TW et. al. (1993) Genetics of essential hypertension.

[^]
50.

Brown DM et. al. (1996) Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

[^]
51.

Gu L et. al. (1996) Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.

[^]
52.

None (1996) Molecular genetics of human blood pressure variation.

[^]
53.

Wu DA et. al. (1996) Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.

[^]
54.

Frossard PM et. al. (1995) Association between a dimorphic site on chromosome 12 and clinical diagnosis of hypertension in three independent populations.

[^]
55.

Pietruck F et. al. (1996) Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.

[^]
56.

Noon JP et. al. (1997) Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure.

[^]
57.

Chiang FT et. al. (1997) Association of the renin gene polymorphism with essential hypertension in a Chinese population.

[^]
58.

Churchill PC et. al. (1997) Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.

[^]
59.

Vincent M et. al. (1997) A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.

[^]
60.

Tanaka M et. al. (1997) Genetically determined chloride-sensitive hypertension and stroke.

[^]
61.

Siffert W et. al. (1998) Association of a human G-protein beta3 subunit variant with hypertension.

[^]
62.

Xu X et. al. (1999) An extreme-sib-pair genome scan for genes regulating blood pressure.

[^]
63.

Baima J et. al. (1999) Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.

[^]
64.

Garbers DL et. al. (1999) The molecular basis of hypertension.

[^]
65.

Glenn CL et. al. (2000) Linkage and association of tumor necrosis factor receptor 2 locus with hypertension, hypercholesterolemia and plasma shed receptor.

[^]
66.

Lifton RP et. al. (2001) Molecular mechanisms of human hypertension.

[^]
67.

Rutherford S et. al. (2001) Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension.

[^]
68.

Yamamoto N et. al. (2002) Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension.

[^]
69.

Angius A et. al. (2002) A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search.

[^]
70.

Nakayama T et. al. (2002) Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.

[^]
71.

Funke-Kaiser H et. al. (2003) Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation.

[^]
72.

DAHL LK et. al. (1962) Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension.

[^]
73.

None (1963) Heredity in hypertension.

[^]
74.

MCDONOUGH JR et. al. (1964) BLOOD PRESSURE AND HYPERTENSIVE DISEASE AMONG NEGROES AND WHITES; A STUDY IN EVANS COUNTY, GEORGIA.

[^]
75.

Rutherford S et. al. (2004) Sibpair studies implicate chromosome 18 in essential hypertension.

[^]
76.

Koivukoski L et. al. (2004) Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3.

[^]
77.

Gainer JV et. al. (2005) Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

[^]
78.

Zhu X et. al. (2005) Admixture mapping for hypertension loci with genome-scan markers.

[^]
79.

Dries DL et. al. (2005) Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.

[^]
80.

Wallace C et. al. (2006) Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.

[^]
81.

Guzmán B et. al. (2006) Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.

[^]
82.

Chang YP et. al. (2007) Multiple genes for essential-hypertension susceptibility on chromosome 1q.

[^]
83.

Rutherford S et. al. (2007) A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.

[^]
84.

Deo RC et. al. (2007) A high-density admixture scan in 1,670 African Americans with hypertension.

[^]
85.

Wang W et. al. (2008) Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.

[^]
86.

Dong N et. al. (2013) Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.

[^]