Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Neigung zu autoimmunbedingten Schilddrüsenerkrankungen

Verschiedenen genetische Loci sind identifiziert worden, die mit autoimmunbedingten Schilddrüsenerkrankungen, wie Hashimoto-Thyreoiditid und Morbus Basedow assoziiert sind.

Gliederung

Störungen des Schilddrüsenhormonsystems
Hyperthyreose
Hypothyreose
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen
Basedow-Krankheit
GC
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen 1
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen 2
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen 3
TG
ZFAT
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen 4
Neigung zu autoimmunbedingten Schilddrüsenerkrankungen 5
Schilddrüsenhormonresistenz
Schilddrüsenkarzinome

Referenzen:

1.

Ban Y et. al. (2003) Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.

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2.

Collins JE et. al. (2004) Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom.

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3.

Caturegli P et. al. (2000) Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid.

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4.

Sakai K et. al. (2001) Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese.

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5.

Shirasawa S et. al. (2004) SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease.

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6.

Hodge SE et. al. (1981) Close genetic linkage between diabetes mellitus and kidd blood group.

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7.

Merriman T et. al. (1997) Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.

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8.

Vaidya B et. al. (2000) Evidence for a new Graves disease susceptibility locus at chromosome 18q21.

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9.

Tomer Y et. al. (2003) Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families.

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10.

Collins JE et. al. (2003) Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease.

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11.

Tomer Y et. al. (1999) Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions.

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12.

Klintschar M et. al. (2001) Evidence of fetal microchimerism in Hashimoto's thyroiditis.

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13.

Alkhateeb A et. al. (2002) Mapping of an autoimmunity susceptibility locus (AIS1) to chromosome 1p31.3-p32.2.

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14.

Ochi H et. al. (2002) Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy.

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15.

Vaidya B et. al. (2002) The genetics of autoimmune thyroid disease.

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16.

Allen EM et. al. (2003) A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3.

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17.

Ueda H et. al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

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18.

Akamizu T et. al. (2003) Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.

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19.

HALL R et. al. (1962) A study of the parents of patients with Hashimoto's disease.

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20.

VOLPE R et. al. (1963) Genetic factors in Hashimoto's struma.

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21.

HALL R et. al. (1964) PATERNAL TRANSMISSION OF THYROID AUTOIMMUNITY.

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22.

MASI AT et. al. (1965) HASHIMOTO'S DISEASE. AN EPIDEMIOLOGICAL CRITIQUE.

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23.

Barbero P et. al. (2004) Choanal atresia associated with prenatal methimazole exposure: three new patients.

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24.

Criswell LA et. al. (2005) Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

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25.

Invernizzi P et. al. (2005) X chromosome monosomy: a common mechanism for autoimmune diseases.

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