Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Nicht-medulläres Schilddrüsenkarzinom

Das nicht-medulläres Schilddrüsenkarzinom ist eine heterogene autosomal dominante Erkrankung der follikulären Schilddrüsenzellen.

Gliederung

Schilddrüsenkarzinome
Familiäres meduläres Schilddrüsenkarzinom
Nicht-medulläres Schilddrüsenkarzinom
Autonomes Schilddrüsenadenom
TSHR
Familiäres folliculäres Schilddrüsenkarzinom
MINPP1
Folliculäres Schilddrüsenkarzinom
HRAS
NRAS
Nicht-medulläres Schilddrüsenkarzinom 1
NKX2-1
Nicht-medulläres Schilddrüsenkarzinom 2
SRGAP1
Nicht-medulläres Schilddrüsenkarzinom 3
Nicht-medulläres Schilddrüsenkarzinom 4
FOXE1
Nicht-medulläres Schilddrüsenkarzinom 5
HABP2
Schilddrüsenkarzinom mit Thyreotoxikose
TSHR

Referenzen:

1.

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2.

Carlomagno F et al. (2003) Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).

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3.

Namba H et al. (2003) Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers.

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4.

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8.

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9.

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13.

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19.

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21.

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22.

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23.

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24.

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25.

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26.

Flannigan GM et al. (1983) Simultaneous presentation of papillary carcinoma of thyroid in a father and son.

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27.

Lote K et al. (1980) Familial occurrence of papillary thyroid carcinoma.

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28.

Phade VR et al. (1981) Familial papillary carcinoma of the thyroid.

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31.

Lesueur F et al. (1999) Genetic heterogeneity in familial nonmedullary thyroid carcinoma: exclusion of linkage to RET, MNG1, and TCO in 56 families. NMTC Consortium.

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32.

Klugbauer S et al. (1999) The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.

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33.

Nikiforova MN et al. (2003) RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

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34.

Dwight T et al. (2003) Involvement of the PAX8/peroxisome proliferator-activated receptor gamma rearrangement in follicular thyroid tumors.

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35.

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36.

Ngan ES et al. (2009) A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma.

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37.

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38.

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39.

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40.

Burgess JR et al. (1997) Two families with an autosomal dominant inheritance pattern for papillary carcinoma of the thyroid.

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41.

Pierotti MA et al. (1996) Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells.

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42.

Bongarzone I et al. (1997) Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.

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43.

Learoyd DL et al. (1998) RET/PTC and RET tyrosine kinase expression in adult papillary thyroid carcinomas.

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44.

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45.

Canzian F et al. (1998) A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2.

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46.

Klugbauer S et al. (1998) Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5.

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47.

Trovato M et al. (1999) Loss of heterozygosity of the long arm of chromosome 7 in follicular and anaplastic thyroid cancer, but not in papillary thyroid cancer.

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48.

Thomas GA et al. (1999) High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.

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49.

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50.

Chua EL et al. (2000) Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia.

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51.

Corvi R et al. (2000) RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.

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52.

Klein M et al. (2001) Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma.

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53.

Hrafnkelsson J et al. (2001) Familial non-medullary thyroid cancer in Iceland.

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54.

Elisei R et al. (2001) RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults.

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55.

Kitamura Y et al. (2001) Allelotyping of follicular thyroid carcinoma: frequent allelic losses in chromosome arms 7q, 11p, and 22q.

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56.

Mechler C et al. (2001) Papillary thyroid carcinoma: 6 cases from 2 families with associated lymphocytic thyroiditis harbouring RET/PTC rearrangements.

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57.

Savagner F et al. (2002) Analysis of Tg transcripts by real-time RT-PCR in the blood of thyroid cancer patients.

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58.

Carlomagno F et al. (2002) The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.

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59.

Finn SP et al. (2003) Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma.

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60.

Baudin E et al. (2003) Positive predictive value of serum thyroglobulin levels, measured during the first year of follow-up after thyroid hormone withdrawal, in thyroid cancer patients.

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Update: 14. August 2020
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