Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Infantiles kapilläres Hämangiom

Das somatische infantile kapilläre Hämangiom ist ein häufiger bei Neugeborenen und Kleinkindern gefundener benigner rötlicher Hauttumor. In den Tumoren finden sich somatische Mutationen in den Genen FLT4 und KDR.

Gliederung

Infantiles kapilläres Hämangiom
FLT4
Infantiles kapilläres Hämangiom
FLT4
Infantiles kapilläres Hämangiom mit Keimbahnmutation

Referenzen:

1.

Walter JW et. al. (2002) Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.

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2.

Blei F et. al. (1998) Familial segregation of hemangiomas and vascular malformations as an autosomal dominant trait.

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3.

Walter JW et. al. (1999) Genetic mapping of a novel familial form of infantile hemangioma.

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4.

Breugem CC et. al. (2002) A locus for hereditary capillary malformations mapped on chromosome 5q.

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5.

Ritter MR et. al. (2002) Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis.

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6.

Waner M et. al. (2003) The nonrandom distribution of facial hemangiomas.

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7.

Spring MA et. al. (2005) Cutaneous vascular lesions.

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8.

Pramanik K et. al. (2009) Dusp-5 and Snrk-1 coordinately function during vascular development and disease.

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9.

Jinnin M et. al. (2008) Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.

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