Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Nichtinsulinabhängiger Diabetes mellitus 1

Der nicht primär insulinabhängige Diabetes mellitus kann durch eine Reihe von Genen begünstigt werden. Die von CAPN10-Mutationen beeinflussten Formen werden als eigene Untergruppe zusammengefasst.

Gliederung

Diabetes mellitus
Autoimmundiabetes
Diabetische Nephropathie
Diabetische Retinopathie
Erbliche Diabetesneigung
Gestationsdiabetes
Insulinresistenz
MODY Diabetes
Mitochondrialer Diabetes mellitus
Neonataler Diabetes mellitus
Nichtinsulinabhängiger Diabetes mellitus 1
CAPN10
Pankreopriver Diabetes mellitus
Schwere Fettsucht mit Typ 2 Diabetes

Referenzen:

1.

Hanis CL et. al. (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

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2.

Altshuler D et. al. (2000) Guilt by association.

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3.

Horikawa Y et. al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.

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4.

None (2001) Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene.

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5.

Kang ES et. al. (2006) A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes.

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6.

Ghosh S et. al. (1998) A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.

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7.

Cox NJ et. al. (1999) Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.

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8.

Busfield F et. al. (2002) A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians.

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