Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Vererbte Magersucht

Bei der vererbte Magersucht liegt eine erblich bedingter besonders schlanker Körperbau vor. Es handelt sich vor allem um eine Ausschlussdiagnose, wobei differentialdiagnostisch Essstörungen und generalisierte Lipodystrophien abzugrenzen sind. Die Störung wird durch Mutationen im AGRP-Gen verursacht.

Gliederung

Störung der Körperfettverteilung
Fettleibigkeit
Lipodystrophie
Vererbte Magersucht
AGRP

Referenzen:

1.

Kitamura T et al. (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

external link
2.

Shutter JR et al. (1997) Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

external link
3.

Ollmann MM et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.

external link
4.

Graham M et al. (1997) Overexpression of Agrt leads to obesity in transgenic mice.

external link
5.

Katsuki A et al. (2001) Plasma levels of agouti-related protein are increased in obese men.

external link
6.

Brown AM et al. (2001) The gene structure and minimal promoter of the human agouti related protein.

external link
7.

Argyropoulos G et al. (2002) A polymorphism in the human agouti-related protein is associated with late-onset obesity.

external link
8.

Marks DL et al. (2004) Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.

external link
9.

Luquet S et al. (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.

external link
10.

Andrews ZB et al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

external link
11.

Atasoy D et al. (2012) Deconstruction of a neural circuit for hunger.

external link
12.

Krashes MJ et al. (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

external link
13.

OMIM.ORG article

Omim 602311 external link
Update: 14. August 2020
Copyright © 2005-2024 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz | Impressum