Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
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Frühzeitig einsetzende Adipositas

Die genetisch bedingte juvenile Adipositas wird durch Mutationen in den Genen POMC und NR0B2 hervorgerufen. Die Vererbung folgt dem dominanten Modell.

Gliederung

Fettleibigkeit
Autosomal dominante Adipositas
BMI-beeinflussender genetischer Faktor
Frühzeitig einsetzende Adipositas
NR0B2
POMC
Neigung zu Fettleibigkeit
Schwere Fettsucht
Schwere Fettsucht mit Typ 2 Diabetes
Spätmanifeste Adipositas

Referenzen:

1.

Ley RE et al. (2006) Microbial ecology: human gut microbes associated with obesity.

external link
2.

Barsh GS et al. (2000) Genetics of body-weight regulation.

external link
3.

Lowell BB et al. (2000) Towards a molecular understanding of adaptive thermogenesis.

external link
4.

Dong C et al. (2003) Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity.

external link
5.

Schadt EE et al. (2003) Genetics of gene expression surveyed in maize, mouse and man.

external link
6.

Stenson PD et al. (2003) Human Gene Mutation Database (HGMD): 2003 update.

external link
7.

None (2003) Genetic medicine and obesity.

external link
8.

Ozcan U et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

external link
9.

Osawa M et al. (2005) Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels.

external link
10.

Dong C et al. (2005) Possible genomic imprinting of three human obesity-related genetic loci.

external link
11.

Bell CG et al. (2005) The genetics of human obesity.

external link
12.

Lavebratt C et al. (2005) AHSG gene variant is associated with leanness among Swedish men.

external link
13.

Sina M et al. (1999) Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene.

external link
14.

Turnbaugh PJ et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest.

external link
15.

Kryukov GV et al. (2007) Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.

external link
16.

Ahituv N et al. (2007) Medical sequencing at the extremes of human body mass.

external link
17.

Barness LA et al. (2007) Obesity: genetic, molecular, and environmental aspects.

external link
18.

Bera TK et al. (2008) A model for obesity and gigantism due to disruption of the Ankrd26 gene.

external link
19.

Chen Y et al. (2008) Variations in DNA elucidate molecular networks that cause disease.

external link
20.

Spalding KL et al. (2008) Dynamics of fat cell turnover in humans.

external link
21.

Qi L et al. (2008) The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women.

external link
22.

Calton MA et al. (2009) Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.

external link
23.

Renström F et al. (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.

external link
24.

Yang X et al. (2009) Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.

external link
25.

Paganini-Hill A et al. (1981) The S-leut anthropometric traits: genetic analysis.

external link
26.

Bahary N et al. (1991) Molecular genetic linkage maps of mouse chromosomes 4 and 6.

external link
27.

Dubern B et al. (2001) Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children.

external link
28.

Farooqi IS et al. (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

external link
29.

Branson R et al. (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.

external link
30.

List JF et al. (2003) Defective melanocortin 4 receptors in hyperphagia and morbid obesity.

external link
31.

Hebebrand J et al. (2004) Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations.

external link
32.

Chambers JC et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance.

external link
33.

Loos RJ et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity.

external link
34.

Willer CJ et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

external link
35.

Jones JM et al. (1992) Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7.

external link
36.

Perry CA et al. (2008) Predisposition to late-onset obesity in GIRK4 knockout mice.

external link
37.

Nishigori H et al. (2001) Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.

external link
38.

Andersen G et al. (2005) Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.

external link
39.

Meyre D et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

external link
40.

Moll PP et al. (1991) The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study.

external link
41.

Bahary N et al. (1990) Molecular mapping of the mouse db mutation.

external link
42.

Bouchard C et al. (1990) The response to long-term overfeeding in identical twins.

external link
43.

Hasstedt SJ et al. (1989) Recessive inheritance of a relative fat pattern.

external link
44.

Roberts SB et al. (1988) Energy expenditure and intake in infants born to lean and overweight mothers.

external link
45.

Ravussin E et al. (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain.

external link
46.

Zonta LA et al. (1987) Genetic analysis of human obesity in an Italian sample.

external link
47.

Stunkard AJ et al. (1986) An adoption study of human obesity.

external link
48.

Norman RA et al. (1997) Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group.

external link
49.

OMIM.ORG article

Omim 601665 external link
Update: 14. August 2020
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