Adipositas ist als eine Erkrankung definiert, bei welcher der BMI (body mass index) größer 30 ist.
Verschiedene genetisch determinierte Formen der Adipositas können unterschieden werden. Diese Formen zeigen unterschiedliche Penetranz, Vererbungdverhalten, und zeitlichen Verlauf.
1. |
Ley RE et al. (2006) Microbial ecology: human gut microbes associated with obesity. |
2. |
Barsh GS et al. (2000) Genetics of body-weight regulation. |
3. |
Lowell BB et al. (2000) Towards a molecular understanding of adaptive thermogenesis. |
4. |
Dong C et al. (2003) Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity. |
5. |
Schadt EE et al. (2003) Genetics of gene expression surveyed in maize, mouse and man. |
6. |
Stenson PD et al. (2003) Human Gene Mutation Database (HGMD): 2003 update. |
7. |
None (2003) Genetic medicine and obesity. |
8. |
Ozcan U et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. |
9. |
Osawa M et al. (2005) Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. |
10. |
Dong C et al. (2005) Possible genomic imprinting of three human obesity-related genetic loci. |
11. |
Bell CG et al. (2005) The genetics of human obesity. |
12. |
Lavebratt C et al. (2005) AHSG gene variant is associated with leanness among Swedish men. |
13. |
Sina M et al. (1999) Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. |
14. |
Turnbaugh PJ et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. |
15. |
Kryukov GV et al. (2007) Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. |
16. |
Ahituv N et al. (2007) Medical sequencing at the extremes of human body mass. |
17. |
Barness LA et al. (2007) Obesity: genetic, molecular, and environmental aspects. |
18. |
Bera TK et al. (2008) A model for obesity and gigantism due to disruption of the Ankrd26 gene. |
19. |
Chen Y et al. (2008) Variations in DNA elucidate molecular networks that cause disease. |
20. |
Spalding KL et al. (2008) Dynamics of fat cell turnover in humans. |
21. |
Qi L et al. (2008) The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. |
22. |
Calton MA et al. (2009) Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. |
23. |
Renström F et al. (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. |
24. |
Yang X et al. (2009) Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. |
25. |
Paganini-Hill A et al. (1981) The S-leut anthropometric traits: genetic analysis. |
26. |
Bahary N et al. (1991) Molecular genetic linkage maps of mouse chromosomes 4 and 6. |
27. |
Dubern B et al. (2001) Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. |
28. |
Farooqi IS et al. (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. |
29. |
Branson R et al. (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. |
30. |
List JF et al. (2003) Defective melanocortin 4 receptors in hyperphagia and morbid obesity. |
31. |
Hebebrand J et al. (2004) Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. |
32. |
Chambers JC et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. |
33. |
Loos RJ et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. |
34. |
Willer CJ et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. |
35. |
Jones JM et al. (1992) Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. |
36. |
Perry CA et al. (2008) Predisposition to late-onset obesity in GIRK4 knockout mice. |
37. |
Nishigori H et al. (2001) Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. |
38. |
Andersen G et al. (2005) Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. |
39. |
Meyre D et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. |
40. |
Moll PP et al. (1991) The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study. |
41. |
Bahary N et al. (1990) Molecular mapping of the mouse db mutation. |
42. |
Bouchard C et al. (1990) The response to long-term overfeeding in identical twins. |
43. |
Hasstedt SJ et al. (1989) Recessive inheritance of a relative fat pattern. |
44. |
Roberts SB et al. (1988) Energy expenditure and intake in infants born to lean and overweight mothers. |
45. |
Ravussin E et al. (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain. |
46. |
Zonta LA et al. (1987) Genetic analysis of human obesity in an Italian sample. |
47. |
Stunkard AJ et al. (1986) An adoption study of human obesity. |
48. |
Norman RA et al. (1997) Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. |
49. |
OMIM.ORG article Omim 601665 |
50. |
Orphanet article Orphanet ID 254898 |
51. |
Wikipedia Artikel Wikipedia DE (Adipositas) |