Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Humorale paraneoplastische Hypercalciämie

Die humorale paraneoplastische Hypercalciämie beruht auf einer Hypersekretion des PTH-related Proteins. Ob auch bestimmte Strukturen innerhalb des PTHLH-Gens einen Einfluss auf diese Fehlsteuerung haben, ist bisher noch nicht geklärt.

Gliederung

Erkrankungen der Nebenschilddrüse
Humorale paraneoplastische Hypercalciämie
PTHLH
Hyperparathyreoidismus
Hypoparathyreoidismus
Karzinom der Nebenschilddrüse
Nebenschilddrüsenadenom
Pseudohyperparathyreoidismus
Pseudohypoparathyreoidismus

Referenzen:

1.

Maass PG et al. (2010) A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.

external link
2.

Kir S et al. (2014) Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

external link
3.

None (2003) 10 years of mouse cancer modifier loci: human relevance.

external link
4.

Hsiao LT et al. (2002) Superior vena cava syndrome and hypercalcaemia in a patient with a primary mediastinal B-cell lymphoma secreting parathyroid hormone-related protein.

external link
5.

Bakre MM et al. (2002) Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor.

external link
6.

Miao D et al. (2002) Parathyroid hormone is essential for normal fetal bone formation.

external link
7.

Manenti G et al. (2000) A cancer modifier role for parathyroid hormone-related protein.

external link
8.

None (2000) The physiology of parathyroid hormone-related protein.

external link
9.

Lanske B et al. (1999) Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.

external link
10.

Philbrick WM et al. (1998) Parathyroid hormone-related protein is required for tooth eruption.

external link
11.

Wysolmerski JJ et al. (1998) Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.

external link
12.

Henry JG et al. (1997) Parathyroid hormone-related protein-(1-36) is biologically active when administered subcutaneously to humans.

external link
13.

Vortkamp A et al. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.

external link
14.

Karaplis AC et al. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

external link
15.

Holick MF et al. (1994) A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice.

external link
16.

Suva LJ et al. (1987) A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

external link
17.

Broadus AE et al. (1988) Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide.

external link
18.

Mangin M et al. (1989) Isolation and characterization of the human parathyroid hormone-like peptide gene.

external link
19.

Moseley JM et al. (1987) Parathyroid hormone-related protein purified from a human lung cancer cell line.

external link
20.

Mangin M et al. (1988) Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.

external link
21.

Yasuda T et al. (1989) Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects.

external link
22.

Hammonds RG et al. (1989) Purification and characterization of recombinant human parathyroid hormone-related protein.

external link
23.

Hendy GN et al. (1990) Gene for parathyroid hormone-like peptide is on mouse chromosome 6.

external link
24.

Wysolmerski JJ et al. (2001) Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction.

external link
25.

Klopocki E et al. (2010) Deletion and point mutations of PTHLH cause brachydactyly type E.

external link
26.

Lanske B et al. (1996) PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.

external link
27.

OMIM.ORG article

Omim 168470 external link
Update: 14. August 2020
Copyright © 2005-2020 Zentrum für Nephrologie und Stoffwechsel, Dr. Mato Nagel
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Deutschland, Tel.: +49-3576-287922, Fax: +49-3576-287944
Seitenüberblick | Webmail | Haftungsausschluss | Datenschutz