Störungen der mRNA-Editiertfunktion
Der Körper verfügt über verschiedene Enzyme, welche die mRNA vor der Translation verändern können. Die Gruppe dieser Enzyme wird als APOBEC zusammengefasst. Das mRNA-Editieren spielt eine wichtige Rolle im Fettstoffwechsel, bei der Infektabwehr (insbesondere viraler Infektionen) und möglicherweise auch in der Tumorgenese. Folglich könnten Störungen in diesen Systemen bei Mutationen der APOBEC-Gene auftreten.
Gliederung
Referenzen:
1. |
Vartanian JP et. al. (2008) Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions. [^] |
2. |
Zhang H et. al. (2003) The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. [^] |
3. |
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4. |
Harris RS et. al. (2003) DNA deamination mediates innate immunity to retroviral infection. [^] |
5. |
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6. |
Marin M et. al. (2003) HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. [^] |
7. |
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8. |
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9. |
Bogerd HP et. al. (2004) A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor. [^] |
10. |
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11. |
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12. |
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13. |
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14. |
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15. |
Chiu YL et. al. (2005) Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. [^] |
16. |
Okeoma CM et. al. (2007) APOBEC3 inhibits mouse mammary tumour virus replication in vivo. [^] |
17. |
Wang T et. al. (2007) 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. [^] |
18. |
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19. |
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20. |
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21. |
Santoni de Sio FR et. al. (2009) APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection. [^] |
22. |
Okeoma CM et. al. (2010) APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions. [^] |
23. |
Rogozin IB et. al. (2005) APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. [^] |
24. |
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