Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
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IgA-Nephropathie Typ 1

Die IgA-Nephropathie vom Typ 1 ist eine wahrscheinlich autosomal dominant vererbte Erkrankung, die an der Chromosomenposition 6q22-q23 festgemacht werden kann. Das zugehörige Gen ist noch nicht bekannt.

Gliederung

IgA-Nephropathie
CFHR1
CFHR3
CFHR5
IgA-Nephropathie Typ 1
IgA-Nephropathie Typ 2
IgA-Nephropathie Typ 3

Referenzen:

1.

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3.

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McCoy RC et al. (1974) IgA nephropathy.

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Croker BP et al. (1983) IgA nephropathy. Correlation of clinical and histologic features.

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Bene MC et al. (1983) Immunoglobulin A nephropathy. Quantitative immunohistomorphometry of the tonsillar plasma cells evidences an inversion of the immunoglobulin A versus immunoglobulin G secreting cell balance.

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10.

Berthoux FC et al. (1978) HLA-Bw35 and mesangial IgA glomerulonephritis.

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11.

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12.

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13.

Katz A et al. (1980) Family study in IgA nephritis: the possible role of HLA antigens.

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14.

Tomana M et al. (1997) Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG.

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15.

Shimokawa T et al. (2000) Identification and characterization of the promoter for the gene encoding the human myeloid IgA Fc receptor (FcalphaR, CD89).

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16.

Tsuge T et al. (2001) Polymorphism in promoter region of Fcalpha receptor gene in patients with IgA nephropathy.

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17.

Obara W et al. (2003) Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients.

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18.

Paterson AD et al. (2007) Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36.

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23.

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Zheng F et al. (1999) Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice.

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Gharavi AG et al. (2000) IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23.

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Hiki Y et al. (2001) Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy.

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29.

Allen AC et al. (2001) Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients.

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31.

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Song J et al. (2003) Gender specific association of aldosterone synthase gene polymorphism with renal survival in patients with IgA nephropathy.

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34.

Wang J et al. (2004) Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy.

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35.

Bisceglia L et al. (2006) Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci.

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36.

Suzuki H et al. (2008) IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.

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37.

None (1989) Familial cases of Berger's disease and anaphylactoid purpura: more frequent than previously thought.

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38.

None (1987) The commonest glomerulonephritis in the world: IgA nephropathy.

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39.

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OMIM.ORG article

Omim 161950 external link
Update: 14. August 2020
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