Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel

Meningokokken-Infektanfälligkeit

Die genetische Anfälligkeit für Meningokokken-Infektionen liegt vor allem in Störungen des Komplementsystems begründet, vor allem der terminale membrane attack complex (MAC), der von C8 und C9 gebildet wird, aber auch Teile des Komplementsystems, die die Bildung des MAC steuern, können betroffen sein (C3, C5, C6, C7).

Management

Die erfolgreiche Prophylaxe besteht in einer Meningokokken-Impfung.

Gliederung

Erbliche Infektionsanfälligkeiten
HIV-Resistenz
IRAK4-Mangel
Invasive Pneumokokken-Erkrankung
Masern-Infektanfälligkeit
Meningokokken-Infektanfälligkeit
C3
C5
C7
C8A
C8B
C8G
C9
CD46
CFB
CFD
CFH
CFP
Resistenz gegenüber Trypanosoma brucei
Septischer Schock
Störungen der mRNA-Editiertfunktion
Suszeptibilität für Bakteriämie 1
Suszeptibilität für Malaria
Suszeptibilität für Mykobakteriosen
Suszeptibilität für Pseudomonas-Infektionen
X-chromosomale Suszeptibilität für Mykobakteriosen durch IKBKG-Defekt

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OMIM.ORG article

Omim 312060 [^]
Update: 10. Mai 2019