Die altersabhängige Makuladegeneration ist eine erbliche immunologisch bedingte Erkrankung, die mit vielen verschiedenen Genen in Zusammenhang gebracht wurde.
Makuladegeneration | ||||
Altersabhängige Makuladegeneration 01 | ||||
APOE | ||||
ARMS2 | ||||
C2 | ||||
C3 | ||||
CFH | ||||
CFHR1 | ||||
CFHR3 | ||||
KCNT2 | ||||
Früheinsetzende Makuladegeneration | ||||
1. |
Klein R et al. (2004) The epidemiology of age-related macular degeneration. |
2. |
Tamer C et al. (2007) Serum dehydroepiandrosterone sulphate level in age-related macular degeneration. |
3. |
Nolan JM et al. (2007) Risk factors for age-related maculopathy are associated with a relative lack of macular pigment. |
4. |
None (2006) Age-related macular degeneration. |
5. |
Imamura Y et al. (2006) Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. |
6. |
Chowers I et al. (2006) The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration. |
7. |
Thornton J et al. (2005) Smoking and age-related macular degeneration: a review of association. |
8. |
Schultz DW et al. (2005) HEMICENTIN-1 (FIBULIN-6) and the 1q31 AMD locus in the context of complex disease: review and perspective. |
9. |
Dunaief JL et al. (2005) Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload. |
10. |
Postel EA et al. (2005) Comparing age-related macular degeneration phenotype in probands from singleton and multiplex families. |
11. |
Ethen CM et al. (2005) Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration. |
12. |
Jonasson F et al. (2005) 5-year incidence of age-related maculopathy in the Reykjavik Eye Study. |
13. |
None (2004) Current concepts in the pathogenesis of age-related macular degeneration. |
14. |
Fisher SA et al. (2007) Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD). |
15. |
Jonas JB et al. (2004) Intravitreal reinjection of triamcinolone for exudative age-related macular degeneration. |
16. |
Grisanti S et al. (2004) Expression of endoglin in choroidal neovascularization. |
17. |
Scholl HP et al. (2004) What is lost by digitizing stereoscopic fundus color slides for macular grading in age-related maculopathy and degeneration? |
18. |
Axer-Siegel R et al. (2004) Association of neovascular age-related macular degeneration and hyperhomocysteinemia. |
19. |
Iyengar SK et al. (2004) Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. |
20. |
Espinosa-Heidmann DG et al. (2004) Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. |
21. |
Schultz DW et al. (2003) Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. |
22. |
Heckenlively JR et al. (2003) Mouse model of subretinal neovascularization with choroidal anastomosis. |
23. |
Hahn P et al. (2003) Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. |
24. |
Danciger M et al. (2003) A strong and highly significant QTL on chromosome 6 that protects the mouse from age-related retinal degeneration. |
25. |
Klein R et al. (2003) Association of emphysema, gout, and inflammatory markers with long-term incidence of age-related maculopathy. |
26. |
De S et al. (2007) Human retinal pigment epithelium cell changes and expression of alphaB-crystallin: a biomarker for retinal pigment epithelium cell change in age-related macular degeneration. |
27. |
Meyers SM et al. (1988) Monozygotic twins with age-related macular degeneration. |
28. |
Fowler BJ et al. (2014) Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. |
29. |
Arakawa S et al. (2011) Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. |
30. |
Kaneko H et al. (2011) DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. |
31. |
Kondo N et al. (2010) Additional evidence to support the role of a common variant near the complement factor I gene in susceptibility to age-related macular degeneration. |
32. |
Takeda A et al. (2009) CCR3 is a target for age-related macular degeneration diagnosis and therapy. |
33. |
Fujihara M et al. (2009) A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD. |
34. |
Lotery A et al. (2007) Progress in defining the molecular biology of age related macular degeneration. |
35. |
Thompson CL et al. (2007) Genetics of pigment changes and geographic atrophy. |
36. |
Li C et al. (2007) Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation. |
37. |
Maruko I et al. (2007) Clinical characteristics of exudative age-related macular degeneration in Japanese patients. |
38. |
Bergeron-Sawitzke J et al. (2009) Multilocus analysis of age-related macular degeneration. |
39. |
Sivaprasad S et al. (2007) Estimation of systemic complement C3 activity in age-related macular degeneration. |
40. |
Kamei M et al. (2007) Scavenger receptors for oxidized lipoprotein in age-related macular degeneration. |
41. |
Bhosale P et al. (2007) Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula. |
42. |
Tan JS et al. (2007) Statins and the long-term risk of incident age-related macular degeneration: the Blue Mountains Eye Study. |
43. |
Schaumberg DA et al. (2007) High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women. |
44. |
Chakravarthy U et al. (2007) Cigarette smoking and age-related macular degeneration in the EUREYE Study. |
45. |
Boekhoorn SS et al. (2007) Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder. |
46. |
Gupta SK et al. (2007) Prevalence of early and late age-related macular degeneration in a rural population in northern India: the INDEYE feasibility study. |
47. |
Kim DH et al. (2007) Strategies for silencing human disease using RNA interference. |
48. |
Decanini A et al. (2007) Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration. |
49. |
Tan JS et al. (2007) Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. |
50. |
Seddon JM et al. (2003) A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. |
51. |
Kanda A et al. (2007) A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. |
52. |
Schaumberg DA et al. (2007) A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors. |
53. |
Dewan A et al. (2006) HTRA1 promoter polymorphism in wet age-related macular degeneration. |
54. |
Conley YP et al. (2006) CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses. |
55. |
Schmidt S et al. (2006) Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. |
56. |
Rivera A et al. (2005) Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. |
57. |
Fisher SA et al. (2005) Meta-analysis of genome scans of age-related macular degeneration. |
58. |
Kenealy SJ et al. (2004) Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. |
59. |
Bhattacharjee A et al. (2003) Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. |
60. |
Jakobsdottir J et al. (2005) Susceptibility genes for age-related maculopathy on chromosome 10q26. |
61. |
Weeks DE et al. (2004) Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. |
62. |
Borrillo JL et al. (2003) Surgical ablation of retinal angiomatous proliferation. |
63. |
Majewski J et al. (2003) Age-related macular degeneration--a genome scan in extended families. |
64. |
Doyle SL et al. (2012) NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. |
65. |
Allikmets R et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3. |
66. |
Edwards AO et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3. |
67. |
Yang Z et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. |
68. |
Kleinman ME et al. (2008) Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. |
69. |
Tarallo V et al. (2012) DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. |
70. |
Seddon JM et al. (2005) Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. |
71. |
Lambooij AC et al. (2003) Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration. |
72. |
Goverdhan SV et al. (2005) Association of HLA class I and class II polymorphisms with age-related macular degeneration. |
73. |
Maller J et al. (2006) Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. |
74. |
Francis PJ et al. (2008) Rhesus monkeys and humans share common susceptibility genes for age-related macular disease. |
75. |
Phipps JA et al. (2003) Loss of cone function in age-related maculopathy. |
76. |
Jonasson F et al. (2003) The prevalence of age-related maculopathy in iceland: Reykjavik eye study. |
77. |
Cousins SW et al. (2003) Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. |
78. |
Malek G et al. (2003) Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. |
79. |
None (2002) New insights and new approaches toward the study of age-related macular degeneration. |
80. |
Crabb JW et al. (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. |
81. |
None (2002) Retinal angiomatous proliferation in age-related macular degeneration. |
82. |
Krzystolik MG et al. (2002) Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. |
83. |
Dithmar S et al. (2001) Murine high-fat diet and laser photochemical model of basal deposits in Bruch membrane. |
84. |
Weeks DE et al. (2001) Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions. |
85. |
Yannuzzi LA et al. (2001) Retinal angiomatous proliferation in age-related macular degeneration. |
86. |
Beatty S et al. () The role of oxidative stress in the pathogenesis of age-related macular degeneration. |
87. |
Weeks DE et al. (2000) A full genome scan for age-related maculopathy. |
88. |
Smith RS et al. (2000) The bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization. |
89. |
Klein ML et al. (1998) Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. |
90. |
Allikmets R et al. (1997) Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. |
91. |
Seddon JM et al. (1997) Familial aggregation of age-related maculopathy. |
92. |
Heiba IM et al. (1994) Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. |
93. |
None (1966) Dystrophy of the macula. |
94. |
Malek G et al. (2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. |
95. |
Fritsche LG et al. (2013) Seven new loci associated with age-related macular degeneration. |
96. |
Ho L et al. (2011) Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study. |
97. |
Fritsche LG et al. (2008) Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. |
98. |
OMIM.ORG article Omim 603075 |