Der kombinierter Hypophysenhormonmangel mit verteifter Halswirbelsäule ist eine autosomal rezessive Erkrankung die durch Mutationen im LHX3-Gen hervorgerufen wird. Neben dem Mangel an fast allen Hypophysenhormonen fällt bei den Patienten eine Versteifung der Halswirbelsäule und eine Innenohrschwerhörigkeit auf.
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