Der Apolipoprotein A1-Mangel ist laborchemisch anhand des Fehlens dieses Proteins im Plasma nachweisbar. Klinisch besteht eine Hypoalphalipoproteinämie mit einem entsprechend erhöhten Risiko für arteriosklerotische Gefäßerkrankungen.
Apolipoprotein-Mangel | ||||
APOA5 | ||||
APOB | ||||
APOC1 | ||||
APOC2 | ||||
APOC3 | ||||
APOE | ||||
APOL1 | ||||
APOM | ||||
Apolipoprotein A1-Mangel | ||||
APOA1 | ||||
Apolipoprotein A2-Mangel | ||||
Apolipoprotein F-Mangel | ||||
Apolipoprotein H-Mangel | ||||
CLU | ||||
1. |
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2. |
Protter AA et al. (1984) Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes. |
3. |
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4. |
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5. |
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6. |
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7. |
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8. |
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9. |
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10. |
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11. |
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12. |
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13. |
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14. |
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15. |
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16. |
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17. |
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18. |
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19. |
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20. |
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21. |
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22. |
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23. |
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24. |
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25. |
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26. |
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27. |
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28. |
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29. |
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30. |
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31. |
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32. |
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33. |
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34. |
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36. |
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37. |
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38. |
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39. |
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40. |
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41. |
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42. |
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43. |
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44. |
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45. |
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47. |
Smith JD et al. (1992) Polymorphism in the human apolipoprotein A-I gene promoter region. Association of the minor allele with decreased production rate in vivo and promoter activity in vitro. |
48. |
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49. |
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50. |
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51. |
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52. |
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53. |
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54. |
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55. |
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56. |
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58. |
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59. |
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60. |
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61. |
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62. |
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63. |
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64. |
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66. |
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67. |
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68. |
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69. |
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70. |
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71. |
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72. |
Karathanasis SK et al. (1987) DNA inversion within the apolipoproteins AI/CIII/AIV-encoding gene cluster of certain patients with premature atherosclerosis. |
73. |
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74. |
Karathanasis SK et al. (1986) Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). |
76. |
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77. |
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78. |
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79. |
Yui Y et al. (1988) Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I. |
80. |
Haddad IA et al. (1986) Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes. |
81. |
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82. |
Frossard PM et al. (1986) ApaI RFLP 5.4 kb 5' to the human apolipoprotein AI (APO A1) gene. |
83. |
Kessling AM et al. (1985) A study of DNA polymorphisms around the human apolipoprotein AI gene in hyperlipidaemic and normal individuals. |
84. |
Rees A et al. (1985) Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia. |
85. |
Antonarakis SE et al. (1988) DNA polymorphism haplotypes of the human apolipoprotein APOA1-APOC3-APOA4 gene cluster. |
86. |
Thompson EA et al. (1988) The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes. |
87. |
None (1988) Apolipoprotein genetic variation and human disease. |
88. |
Stocks J et al. (1987) Haplotypes identified by DNA restriction-fragment-length polymorphisms in the A-1 C-III A-IV gene region and hypertriglyceridemia. |
89. |
Hayden MR et al. (1987) DNA polymorphisms in and around the Apo-A1-CIII genes and genetic hyperlipidemias. |
90. |
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91. |
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92. |
OMIM.ORG article Omim 107680 |