Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Masern-Infektanfälligkeit

Es gibt genetische Faktoren, die Masern-infektionen beeinflussen können. Solche genetischen Faktoren können sowohl eine erhöhte Anfälligkeit, aber auch eine Resistenz bewirken. Manche haben Einfluss auf das Ergebnis einer Immunisierung (Impfung).

Gliederung

Erbliche Infektionsanfälligkeiten
Aspergillose-Infektionsanfälligkeit
Familiäre Candidose
HIV-Resistenz
IRAK4-Mangel
Invasive Pneumokokken-Erkrankung
Masern-Infektanfälligkeit
CD46
Meningokokken-Infektanfälligkeit
Resistenz gegenüber Trypanosoma brucei
Septischer Schock
Störungen der mRNA-Editiertfunktion
Suszeptibilität für Bakteriämie 1
Suszeptibilität für Malaria
Suszeptibilität für Mykobakteriosen
Suszeptibilität für Pseudomonas-Infektionen
X-chromosomale Suszeptibilität für Mykobakteriosen durch IKBKG-Defekt

Referenzen:

1.

Xiang L et al. (1999) Quantitative alleles of CR1: coding sequence analysis and comparison of haplotypes in two ethnic groups.

external link
2.

Warwicker P et al. (1998) Genetic studies into inherited and sporadic hemolytic uremic syndrome.

external link
3.

Santoro F et al. (1999) CD46 is a cellular receptor for human herpesvirus 6.

external link
4.

Tatsuo H et al. (2000) SLAM (CDw150) is a cellular receptor for measles virus.

external link
5.

Källström H et al. (2001) Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence.

external link
6.

Marie JC et al. (2002) Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation.

external link
7.

Kemper C et al. (2003) Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype.

external link
8.

Schneider-Schaulies J et al. (2003) Measles infection of the central nervous system.

external link
9.

Johansson L et al. (2003) CD46 in meningococcal disease.

external link
10.

Richards A et al. (2003) Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome.

external link
11.

Gaggar A et al. (2003) CD46 is a cellular receptor for group B adenoviruses.

external link
12.

Noris M et al. (2003) Familial haemolytic uraemic syndrome and an MCP mutation.

external link
13.

Esparza-Gordillo J et al. (2005) Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32.

external link
14.

Fremeaux-Bacchi V et al. (2005) The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts.

external link
15.

Gaggar A et al. (2005) Localization of regions in CD46 that interact with adenovirus.

external link
16.

Cassiani-Ingoni R et al. (2005) CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion.

external link
17.

Yanagi Y et al. (2006) Measles virus receptors and tropism.

external link
18.

Tishon A et al. (2006) CD4 T cell control primary measles virus infection of the CNS: regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective.

external link
19.

Sood R et al. (2006) Gene expression patterns in human placenta.

external link
20.

Caprioli J et al. (2006) Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome.

external link
21.

Yanagi Y et al. (2006) Measles virus: cellular receptors, tropism and pathogenesis.

external link
22.

Post TW et al. (1991) Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.

external link
23.

Oliaro J et al. (2006) Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation.

external link
24.

Karosi T et al. (2008) Disease-associated novel CD46 splicing variants and pathologic bone remodeling in otosclerosis.

external link
25.

Yanagi Y et al. (2009) Measles virus receptors.

external link
26.

Kemper C et al. (2009) Measles virus and CD46.

external link
27.

Purcell DF et al. (1991) Identification of four different CD46 (MCP) molecules with anti-peptide antibodies.

external link
28.

Santiago C et al. (2010) Structure of the measles virus hemagglutinin bound to the CD46 receptor.

external link
29.

Haralambieva IH et al. (2011) Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine.

external link
30.

Ovsyannikova IG et al. (2011) The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms.

external link
31.

Andrews PW et al. (1985) A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on human chromosome 1.

external link
32.

Bora NS et al. (1989) Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene.

external link
33.

Lublin DM et al. (1988) Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.

external link
34.

Pirson Y et al. (1987) Hemolytic uremic syndrome in three adult siblings: a familial study and evolution.

external link
35.

McIntyre JA et al. (1983) Human trophoblast-lymphocyte cross-reactive (TLX) antigens define a new alloantigen system.

external link
36.

Cui W et al. (1993) Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element.

external link
37.

Dörig RE et al. (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain).

external link
38.

Källström H et al. (1997) Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria.

external link
39.

Teles RM et al. (2013) Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.

external link
40.

Fields PE et al. (2002) Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.

external link
41.

Wathelet MG et al. (1988) Cloning and chromosomal location of human genes inducible by type I interferon.

external link
42.

Bass BL et al. (1988) An unwinding activity that covalently modifies its double-stranded RNA substrate.

external link
43.

Wang Y et al. (1995) Genomic organization and chromosomal location of the human dsRNA adenosine deaminase gene: the enzyme for glutamate-activated ion channel RNA editing.

external link
44.

Patterson JB et al. (1995) Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.

external link
45.

O'Connell MA et al. (1995) Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase.

external link
46.

Kim U et al. (1994) Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

external link
47.

Weier HU et al. (1995) The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2.

external link
48.

Weier HU et al. (2000) Assignment of the RNA-specific adenosine deaminase gene (Adar) to mouse chromosome 3F2 by in situ hybridization.

external link
49.

Wang Q et al. (2000) Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.

external link
50.

Herbert A et al. (2002) Induction of protein translation by ADAR1 within living cell nuclei is not dependent on RNA editing.

external link
51.

Miyamura Y et al. (2003) Mutations of the RNA-specific adenosine deaminase gene (DSRAD) are involved in dyschromatosis symmetrica hereditaria.

external link
52.

Tojo K et al. (2006) Dystonia, mental deterioration, and dyschromatosis symmetrica hereditaria in a family with ADAR1 mutation.

external link
53.

Chao SC et al. () A novel nonsense mutation of the DSRAD gene in a Taiwanese family with dyschromatosis symmetrica hereditaria.

external link
54.

Xing Q et al. () Novel deletion mutation of DSRAD in a Chinese family with Dyschromatosis Symmetrica Hereditaria (DSH).

external link
55.

Agranat L et al. (2008) The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.

external link
56.

Rice GI et al. (2012) Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.

external link
57.

Justice MJ et al. (1990) A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.

external link
58.

None (1977) The status of interferon.

external link
59.

Creagan RP et al. (1975) Somatic cell genetic analysis of the interferon system.

external link
60.

Shimizu A et al. (1992) A molecular genetic linkage map of mouse chromosome 10, including the Myb, S100b, Pah, Sl, and Ifg genes.

external link
61.

Tzoneva M et al. (1988) Selective immunodeficiency with defect in interferon-gamma induction in two sibs with recurrent infections.

external link
62.

Luster AD et al. () Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.

external link
63.

Lipinski M et al. (1980) Natural killer and killer cell activities in patients with primary immunodeficiencies or defects in immune interferon production.

external link
64.

Mantei N et al. (1980) The nucleotide sequence of a cloned human leukocyte interferon cDNA.

external link
65.

Blalock JE et al. (1980) Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.

external link
66.

Maeda S et al. (1980) Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon.

external link
67.

Devos R et al. (1982) Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.

external link
68.

Yip YK et al. (1982) Purification of two subspecies of human gamma (immune) interferon.

external link
69.

Gray PW et al. (1982) Structure of the human immune interferon gene.

external link
70.

Naylor SL et al. (1983) Human immune interferon gene is located on chromosome 12.

external link
71.

Nathan CF et al. (1983) Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

external link
72.

Trent JM et al. (1982) Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization.

external link
73.

Knight E et al. (1980) Human fibroblast interferon: amino acid analysis and amino terminal amino acid sequence.

external link
74.

Zoon KC et al. (1980) Amino terminal sequence of the major component of human lymphoblastoid interferon.

external link
75.

Zimonjic DB et al. (1995) Mapping of the immune interferon gamma gene (IFNG) to chromosome band 12q14 by fluorescence in situ hybridization.

external link
76.

Bureau JF et al. (1995) The gene coding for interferon-gamma is linked to the D12S335 and D12S313 microsatellites and to the MDM2 gene.

external link
77.

Diaz MO et al. (1993) Nomenclature of the human interferon genes.

external link
78.

Tsubota K et al. (1999) Regulation of human leukocyte antigen expression in human conjunctival epithelium.

external link
79.

Pravica V et al. (1999) In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.

external link
80.

Diefenbach A et al. (1999) Requirement for type 2 NO synthase for IL-12 signaling in innate immunity.

external link
81.

Awad M et al. (1999) CA repeat allele polymorphism in the first intron of the human interferon-gamma gene is associated with lung allograft fibrosis.

external link
82.

Bream JH et al. (2000) Polymorphisms of the human IFNG gene noncoding regions.

external link
83.

White AC et al. (2000) Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion.

external link
84.

Khani-Hanjani A et al. (2000) Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis.

external link
85.

Pravica V et al. (2000) A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production.

external link
86.

Badovinac VP et al. (2000) Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

external link
87.

Takayanagi H et al. (2000) T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

external link
88.

Zohlnhöfer D et al. (2001) Transcriptome analysis reveals a role of interferon-gamma in human neointima formation.

external link
89.

Binder GK et al. (2001) Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons.

external link
90.

Cavet J et al. (2001) Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation.

external link
91.

Szabo SJ et al. (2002) Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

external link
92.

Ben-Asouli Y et al. (2002) Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR.

external link
93.

Dabora SL et al. (2002) Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients.

external link
94.

Messi M et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

external link
95.

Rossouw M et al. (2003) Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene.

external link
96.

An P et al. (2003) A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals.

external link
97.

Dufour C et al. (2004) Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population.

external link
98.

Koh KP et al. (2004) T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase.

external link
99.

Spilianakis CG et al. (2005) Interchromosomal associations between alternatively expressed loci.

external link
100.

Chang S et al. (2005) Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells.

external link
101.

Cooke GS et al. (2006) Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.

external link
102.

Huang Y et al. (2007) A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection.

external link
103.

Barton ES et al. (2007) Herpesvirus latency confers symbiotic protection from bacterial infection.

external link
104.

Schoenborn JR et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses.

external link
105.

Kosaka H et al. (2008) Interferon-gamma is a therapeutic target molecule for prevention of postoperative adhesion formation.

external link
106.

Pacheco AG et al. (2008) IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study.

external link
107.

King VL et al. (2009) Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture.

external link
108.

Baldridge MT et al. (2010) Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.

external link
109.

Zaidi MR et al. (2011) Interferon-γ links ultraviolet radiation to melanomagenesis in mice.

external link
110.

Zielinski CE et al. (2012) Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

external link
111.

Braumüller H et al. (2013) T-helper-1-cell cytokines drive cancer into senescence.

external link
112.

Webb GC et al. (1990) Mapping the gene for murine T-cell growth factor, Il-2, to bands B-C on chromosome 3 and for the alpha chain of the IL2-receptor, Il-2ra, to bands A2-A3 on chromosome 2.

external link
113.

Leonard WJ et al. (1985) Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.

external link
114.

Rickert M et al. (2005) The structure of interleukin-2 complexed with its alpha receptor.

external link
115.

Wang X et al. (2005) Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

external link
116.

Kato H et al. (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.

external link
117.

Imaizumi T et al. (2002) Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2.

external link
118.

Cui XF et al. (2004) Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells.

external link
119.

Yoneyama M et al. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

external link
120.

Imaizumi T et al. (2004) Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma.

external link
121.

Imaizumi T et al. () Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells.

external link
122.

Li K et al. (2005) Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.

external link
123.

Breiman A et al. (2005) Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.

external link
124.

Kato H et al. (2005) Cell type-specific involvement of RIG-I in antiviral response.

external link
125.

Pichlmair A et al. (2006) RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.

external link
126.

Hornung V et al. (2006) 5'-Triphosphate RNA is the ligand for RIG-I.

external link
127.

Saito T et al. (2007) Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.

external link
128.

Gack MU et al. (2007) TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

external link
129.

Arimoto K et al. (2007) Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.

external link
130.

Zhang NN et al. (2008) RIG-I plays a critical role in negatively regulating granulocytic proliferation.

external link
131.

Myong S et al. (2009) Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

external link
132.

Oshiumi H et al. (2010) The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.

external link
133.

Kok KH et al. (2011) The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response.

external link
134.

Jiang F et al. (2011) Structural basis of RNA recognition and activation by innate immune receptor RIG-I.

external link
135.

Lyons PA et al. (2000) Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.

external link
136.

Ku CC et al. (2000) Control of homeostasis of CD8+ memory T cells by opposing cytokines.

external link
137.

Ghosh A et al. (2001) A specific isozyme of 2'-5' oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family.

external link
138.

Gebert B et al. (2003) Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation.

external link
139.

Ferlazzo G et al. (2004) The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic.

external link
140.

King C et al. (2004) Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

external link
141.

Bonnevie-Nielsen V et al. (2005) Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.

external link
142.

Field LL et al. (2005) OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes.

external link
143.

Williams MA et al. (2006) Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

external link
144.

Rutherford MN et al. (1991) The murine 2-5A synthetase locus: three distinct transcripts from two linked genes.

external link
145.

Yamanouchi J et al. (2007) Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

external link
146.

Lim JK et al. (2009) Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.

external link
147.

Bigham AW et al. (2011) Host genetic risk factors for West Nile virus infection and disease progression.

external link
148.

Weinberg K et al. (1990) Severe combined immunodeficiency due to a specific defect in the production of interleukin-2.

external link
149.

Benech P et al. (1985) Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.

external link
150.

Williams BR et al. (1986) Interferon-regulated human 2-5A synthetase gene maps to chromosome 12.

external link
151.

Bonnevie-Nielsen V et al. (1989) Association of IDDM and attenuated response of 2',5'-oligoadenylate synthetase to yellow fever vaccine.

external link
152.

Fiorentino L et al. (1989) Assignment of the interleukin-2 locus to mouse chromosome 3.

external link
153.

Smith KA et al. (1985) Interleukin 2 regulates its own receptors.

external link
154.

Depper JM et al. (1985) Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

external link
155.

Greene WC et al. (1986) The human interleukin-2 receptor.

external link
156.

None (1988) Interleukin-2: inception, impact, and implications.

external link
157.

Wathelet M et al. (1986) Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.

external link
158.

Lowenthal JW et al. () Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes.

external link
159.

Clark SC et al. (1984) Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells.

external link
160.

Seigel LJ et al. (1984) Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.

external link
161.

Degrave W et al. (1983) Cloning and structure of the human interleukin 2 chromosomal gene.

external link
162.

Fujita T et al. (1983) Structure of the human interleukin 2 gene.

external link
163.

Merlin G et al. (1983) Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells.

external link
164.

Rosenberg SA et al. (1984) Biological activity of recombinant human interleukin-2 produced in Escherichia coli.

external link
165.

Taniguchi T et al. () Structure and expression of a cloned cDNA for human interleukin-2.

external link
166.

Cantrell DA et al. (1984) The interleukin-2 T-cell system: a new cell growth model.

external link
167.

Stern AS et al. (1984) Purification to homogeneity and partial characterization of interleukin 2 from a human T-cell leukemia.

external link
168.

Holbrook NJ et al. (1984) T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.

external link
169.

Shows T et al. (1984) Interleukin 2 (IL2) is assigned to human chromosome 4.

external link
170.

Holländer GA et al. (1998) Monoallelic expression of the interleukin-2 locus.

external link
171.

Hovnanian A et al. (1998) The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.

external link
172.

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