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Basedow-Krankheit

Morbus Basedow ist eine Hyperthyreose-Syndrom, welches von Struma, Exophthalmus und gelegentlich auch von einem prätibialen Myxödem begleited wird. Ein wichtiges Merkmal sind den TSH-Rezeptor stimmulierende Autoantikörper, die zu einer vermehrten Produktion und Sekretion von Schilddrüsenhormonen und Struma-Wachstum führen.

Gliederung

Hyperthyreose
Basedow-Krankheit
GC
Familiäre Schwangerschaftshyperthyreose
McCune-Albright-Syndrom
Neigung zur thyreotoxischen periodischen Paralyse 1
Nicht-autoimmunbedingte Hyperthyreose

Referenzen:

1.

None (1972) Genetics of Graves' disease.

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2.

MARTIN L et al. (1951) The hereditary and familial aspects of toxic nodular goitre (secondary thyrotoxicosis).

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3.

Simmonds MJ et al. (2005) Regression mapping of association between the human leukocyte antigen region and Graves disease.

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4.

Sutherland A et al. (2007) Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.

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5.

Brand OJ et al. (2009) Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease.

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6.

None (1945) The hereditary and familial aspects of exophthalmic goitre and nodular goitre.

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7.

None (1990) Receptor autoimmunity in endocrine disorders.

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8.

Payami H et al. (1989) Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease.

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9.

Wit JM et al. (1986) Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis.

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10.

Horwitz DL et al. (1977) Graves' disease associated with familial deficiency of thyroxine-binding globulin.

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11.

Chu X et al. (2011) A genome-wide association study identifies two new risk loci for Graves' disease.

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12.

Uno H et al. (1981) Two major genes, linked to HLA and Gm, control susceptibility to Graves' disease.

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13.

Bahn RS et al. (1993) Pathogenesis of Graves' ophthalmopathy.

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14.

Shimojo N et al. (1996) Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule.

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15.

de Roux N et al. (1996) Analysis of the thyrotropin receptor as a candidate gene in familial Graves' disease.

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16.

Tomer Y et al. (1997) Mapping of a major susceptibility locus for Graves' disease (GD-1) to chromosome 14q31.

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17.

None (1976) Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis.

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18.

Barbesino G et al. (1998) Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease.

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19.

Heward JM et al. (1998) Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: replication using a population case control and family-based study.

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20.

Robertson DM et al. (2003) Retinal microvascular abnormalities in patients treated with external radiation for graves ophthalmopathy.

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21.

Ueda H et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

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22.

Chen CR et al. (2003) The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim.

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23.

Hiratani H et al. (2005) Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease.

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24.

Dechairo BM et al. (2005) Association of the TSHR gene with Graves' disease: the first disease specific locus.

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25.

Paschke R et al. (1997) The thyrotropin receptor in thyroid diseases.

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26.

Akamizu T et al. (2003) Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.

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27.

Barbero P et al. (2004) Choanal atresia associated with prenatal methimazole exposure: three new patients.

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28.

Ban Y et al. (2000) Vitamin D receptor gene polymorphism is associated with Graves' disease in the Japanese population.

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29.

Donner H et al. (1997) CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus.

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30.

Vaidya B et al. (1999) The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus.

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31.

Chen QY et al. (1999) HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective.

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32.

Farid NR et al. (1979) A study of human leukocyte D locus related antigens in Graves' disease.

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33.

Pearce SH et al. (1999) Further evidence for a susceptibility locus on chromosome 20q13.11 in families with dominant transmission of Graves disease.

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34.

Chen QY et al. (2000) The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype is associated with Graves' disease in African Americans.

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35.

Marcocci C et al. (2001) Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study.

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36.

Hermenegildo C et al. (2002) Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients.

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37.

Hadj Kacem H et al. (2003) PDS is a new susceptibility gene to autoimmune thyroid diseases: association and linkage study.

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38.

Kretowski A et al. (2003) Intercellular adhesion molecule 1 gene polymorphisms in Graves' disease.

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39.

OMIM.ORG article

Omim 275000 external link
40.

Wikipedia Artikel

Wikipedia DE (Morbus_Basedow) external link
Update: 14. August 2020
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