Die IgA-Nephropathie ist die häufigste Form der mesangioproliferativen Glomerulonephritis und der Glomerulonephritiden insgesamt. Immunhistologisch ist es eine mesangioproliferative Glomerulonephritis mit verstärkter IgA-Ablagerung. Meist ist auch im Serum ein erhöhter IgA-Spiegel nachweisbar.
Der Verlauf der IgA-Nephropathie ist individuell sehr unterschiedlich. Während einige Patienten über Jahre stabil bleiben, gelangen andere relativ rasch in das Stadium der terminalen Niereninsuffizienz. Die Ursachen für diese individuellen Unterschiede sind noch bei weitem nicht aufgeklärt. Neben der effektiven Blutdrucksenkung mit einer Blockade des Renin-Angiotensin-Systems und diätetischen Maßnahmen (Polyen-Fettsäuren sog. Fischöl) scheinen auch genetische Faktoren eine Rolle zu spielen.
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Wikipedia Artikel Wikipedia DE (IgA-Nephritis) |