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IgA-Nephropathie

Die IgA-Nephropathie ist die häufigste Form der mesangioproliferativen Glomerulonephritis und der Glomerulonephritiden insgesamt. Immunhistologisch ist es eine mesangioproliferative Glomerulonephritis mit verstärkter IgA-Ablagerung. Meist ist auch im Serum ein erhöhter IgA-Spiegel nachweisbar.

Klinischer Befund

Der Verlauf der IgA-Nephropathie ist individuell sehr unterschiedlich. Während einige Patienten über Jahre stabil bleiben, gelangen andere relativ rasch in das Stadium der terminalen Niereninsuffizienz. Die Ursachen für diese individuellen Unterschiede sind noch bei weitem nicht aufgeklärt. Neben der effektiven Blutdrucksenkung mit einer Blockade des Renin-Angiotensin-Systems und diätetischen Maßnahmen (Polyen-Fettsäuren sog. Fischöl) scheinen auch genetische Faktoren eine Rolle zu spielen.

Gliederung

Mesangioproliferative Glomerulonephritis
CXCR1
IgA-Nephropathie
CFHR1
CFHR3
CFHR5
IgA-Nephropathie Typ 1
IgA-Nephropathie Typ 2
IgA-Nephropathie Typ 3
SPRY2
Komplement C1q-Mangel
Schimke-Dysplasie
Wiskott-Aldrich-Syndrom

Referenzen:

1.

McCoy RC et al. (1974) IgA nephropathy.

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2.

None (1987) The commonest glomerulonephritis in the world: IgA nephropathy.

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3.

Julian BA et al. (1988) IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States?

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4.

Asamoah A et al. (1987) A major gene model for the familial aggregation of plasma IgA concentration.

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5.

Coppo R et al. (1986) Dietary gluten and primary IgA nephropathy.

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6.

Julian BA et al. (1985) Familial IgA nephropathy. Evidence of an inherited mechanism of disease.

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7.

Jennette JC et al. (1985) Low incidence of IgA nephropathy in blacks.

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8.

None (1969) IgA glomerular deposits in renal disease.

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9.

Sabatier JC et al. (1979) Mesangial IgA glomerulonephritis in HLA-identical brothers.

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10.

Yoshida H et al. (1995) Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy.

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11.

Croker BP et al. (1983) IgA nephropathy. Correlation of clinical and histologic features.

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12.

Bene MC et al. (1983) Immunoglobulin A nephropathy. Quantitative immunohistomorphometry of the tonsillar plasma cells evidences an inversion of the immunoglobulin A versus immunoglobulin G secreting cell balance.

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13.

Berthoux FC et al. (1978) HLA-Bw35 and mesangial IgA glomerulonephritis.

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14.

Brettle R et al. (1978) Mesangial IgA glomerulonephritis and HLA antigens.

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15.

Tolkoff-Rubin NE et al. (1978) IGA nephropathy in HLA-identical siblings.

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16.

Katz A et al. (1980) Family study in IgA nephritis: the possible role of HLA antigens.

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17.

Tomana M et al. (1997) Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG.

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18.

Suzuki H et al. (2008) IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.

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19.

Pei Y et al. (1997) Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.

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20.

Scolari F et al. (1999) Familial clustering of IgA nephropathy: further evidence in an Italian population.

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21.

Segerer S et al. (1999) Expression of the C-C chemokine receptor 5 in human kidney diseases.

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22.

Zheng F et al. (1999) Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice.

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23.

Hsu SI et al. (2000) Evidence for genetic factors in the development and progression of IgA nephropathy.

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24.

Gharavi AG et al. (2000) IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23.

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25.

Hiki Y et al. (2001) Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy.

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26.

Allen AC et al. (2001) Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients.

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27.

Takei T et al. (2002) Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy.

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28.

Donadio JV et al. (2002) IgA nephropathy.

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29.

Yoon HJ et al. (2003) Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy.

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30.

Song J et al. (2003) Gender specific association of aldosterone synthase gene polymorphism with renal survival in patients with IgA nephropathy.

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31.

Wang J et al. (2004) Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy.

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32.

Bisceglia L et al. (2006) Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci.

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33.

None (1989) Familial cases of Berger's disease and anaphylactoid purpura: more frequent than previously thought.

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34.

OMIM.ORG article

Omim 161950 external link
35.

Wikipedia Artikel

Wikipedia DE (IgA-Nephritis) external link
Update: 14. August 2020
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